Ala-Gln双肽肠外营养对胃肠道肿瘤化疗患者相关免疫学及负氮平衡的影响研究  

Effects of Ala-Gln dipeptide parenteral nutrition on immunology and negative nitrogen balance in patients with gastrointestinal cancer undergoing chemotherapy

作　　者：王晓兰 杨勇[2] 蒲汪洋[3] 潘杰[1] WANG Xiaolan;YANG Yong;PU Wangyang;PAN Jie(Department of Pharmacy,the Second Affiliated Hospital of Suzhou University,Suzhou 215000,China;Department of Laboratory,the Second Affiliated Hospital of Suzhou University,Suzhou 215000,China;Department of Oncology,the Second Affiliated Hospital of Suzhou University,Suzhou 215000,China)

机构地区：[1]苏州大学附属第二医院药剂科,江苏苏州215000 [2]苏州大学附属第二医院检验科,江苏苏州215000 [3]苏州大学附属第二医院肿瘤科,江苏苏州215000

出　　处：《胃肠病学和肝病学杂志》2020年第8期903-906,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：苏州市药学会资助项目(SYSD2018235)。

摘　　要：目的观察Ala-Gln双肽肠外营养在胃肠道肿瘤化疗患者中的应用效果,及对患者免疫学指标和负氮平衡的影响。方法选取2013年5月至2016年5月在我院接受化疗且进行肠外营养的胃肠道肿瘤患者为研究对象,根据其营养方式的不同分为常规肠外营养组(对照组)和Ala-Gln双肽肠外营养组(观察组)。观察两组患者治疗前后营养指标、免疫功能和负氮平衡的差异。结果两组患者治疗前营养指标差异无统计学意义(P>0.05),治疗7 d后,观察组患者的PALB、TRF、ALB水平高于对照组患者(t=-11.043、-18.636、-7.331,P<0.001);两组患者治疗前免疫指标差异无统计学意义(P>0.05),治疗7 d后,观察组患者的IgG、IgA、IgM水平高于对照组患者(t=-6.966、-6.886、-4.155,P<0.001);两组患者治疗前负氮水平差异无统计学意义(P>0.05),治疗7 d后,观察组患者的负氮水平低于对照组患者(t=16.407,P<0.001)。结论 Ala-Gln双肽肠外营养在胃肠道肿瘤化疗患者中的应用效果较好,可明显改善患者的营养状况和负氮平衡,具有良好的临床应用价值。Objective To observe the effect of Ala-Gln dipeptide parenteral nutrition in patients with gastrointestinal cancer undergoing chemotherapy, and its influence on immunological parameters and negative nitrogen balance. Methods Patients with gastrointestinal cancer who received chemotherapy and parenteral nutrition in our hospital from May 2013 to May 2016 were selected as the study subjects. According to the different nutritional modes, they were divided into routine parenteral nutrition group(control group) and Ala-Gln dipeptide parenteral nutrition group(observation group). The differences of nutritional index, immune function and negative nitrogen balance between two groups before and after treatment were observed. Results There was no difference in nutritional indicators before treatment between two groups(P>0.05). After 7 days of treatment, the levels of PALB, TRF and ALB in observation group were higher than those in control group(t=-11.043,-18.636,-7.331, P<0.001);there was no difference in immune indicators before treatment between two groups(P>0.05). After 7 days of treatment, the levels of IgG, IgA and IgM in observation group were higher than those in control group(t=-6.966,-6.886,-4.155, P<0.001). There was no difference in the level of negative nitrogen before treatment(P>0.05). After 7 days of treatment, the level of negative nitrogen in observation group was lower than that in control group(t=16.407, P<0.001). Conclusion The application of Ala-Gln dipeptide parenteral nutrition in patients with gastrointestinal cancer undergoing chemotherapy is effective, which can significantly improve the nutritional status and negative nitrogen balance of patients, and has good clinical application value.

关 键 词：肠外营养 胃肠道肿瘤 负氮平衡 营养指标 免疫功能 

分 类 号：R735[医药卫生—肿瘤]