艾司西酞普兰联合经颅磁刺激治疗难治性精神分裂症患者阴性症状的效果  

Effect of esmcitalop combined with transcranial magnetic stimulation on negative symptoms in patients with refractory schizophrenia

作　　者：梁玉霞 宋丽 吴俊红 Liang Yuxia;Song Li;Wu Junhong(Second Department of PsychiatryⅡ,Zhumadian Second People’s Hospital,Zhumadian 463000,China)

机构地区：[1]河南省驻马店市第二人民医院精神二科,463000

出　　处：《中国实用医刊》2020年第10期64-67,共4页Chinese Journal of Practical Medicine

摘　　要：目的:探讨艾司西酞普兰联合经颅磁刺激治疗对难治性精神分裂症患者阴性症状的影响。方法:抽取2015年6月至2019年6月驻马店市第二人民医院收治的70例难治性精神分裂症患者患者为对象,按照随机数字法分为对照组(n=35)和观察组(n=35),对照组给予艾司西酞普兰治疗,观察组给予艾司西酞普兰联合经颅磁刺激治疗,比较两组临床疗效、阴性症状(SANS)评分、个人和社会功能(PSP)评分、抑郁症状(HAMD)评分及不良反应发生率。结果:治疗后观察组总有效率(85.71%)高于对照组(65.71%,P<0.05);治疗后观察组情感淡漠、思维贫乏、意志缺乏、兴趣缺乏、注意障碍及总分低于对照组(P<0.05);治疗后观察组PSP评分高于对照组,HAMD评分低于对照组(P<0.05);两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论:艾司西酞普兰联合经颅磁刺激治疗难治性分裂症患者疗效显著,可有效改善阴性症状,且安全性较高。Objective To explore the effects of escitalopram combined with transcranial magnetic stimulation(TMS)on negative symptoms in patients with refractory schizophrenia.Methods Seventy patients with refractory schizophrenia who were admitted to the Zhumadian Second People’s Hospital from June 2015 to June 2019 were enrolled.They were divided into control group(n=35)and observation group(n=35)by random number table method.The control group was treated with escitalopram,while observation group was treated with escitalopram combined with TMS.The clinical curative effect,scores of negative symptom scale(SANS),personal and social performance scale(PSP),Hamilton Depression Scale(HAMD)and incidence of adverse reactions were compared between the two groups.Results After treatment,total response rate in observation group was significantly higher than that in control group(85.71%vs.65.71%,P<0.05).After treatment,scores of apathy,lack of thinking,will and interest,attention disorder and total score in observation group were lower than those in control group(P<0.05).After treatment,PSP score of observation group was higher than that of control group,while HAMD score was lower than that of control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusions The combination of escitalopram and transcranial magnetic stimulation is effective in the treatment of refractory schizophrenia.It can improve the negative symptoms effectively and has high safety.

关 键 词：艾司西酞普兰 难治性分裂症 经颅磁刺激 阴性症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]