Neuromuscular junction mitochondrial enrichment: a “double-edged sword” underlying the selective motor neuron vulnerability in amyotrophic lateral sclerosis  

作　　者：Topaz Altman Eran Perlson 

机构地区：[1]Department of Physiology and Pharmacology,Sackler Faculty of Medicine,Tel-Aviv University,Tel-Aviv,Israel [2]Sagol School of Neuroscience,Tel-Aviv University,Tel-Aviv,Israel

出　　处：《Neural Regeneration Research》2021年第1期115-116,共2页中国神经再生研究（英文版）

摘　　要：Motor neurons are highly polarized cells,with long axons that extend to more than 1 m in the adult human.The axons further arborize into a specialized synaptic compartment,the motor unit,containing up to 2000 neuromuscular junctions(NMJs).While the size of other neuronal synapses can be up to 1μm,the NMJ is much larger and can reach 10–30μm(Jones et al.,2017).The vast size of the motor unit requires motor neurons to evolutionally adapt and supply this distal portion with a sufficient amount of ATP,as well as to replenish the axonal protein pool in order to maintain their synapses.

关 键 词：specialized MAINTAIN SWORD 

分 类 号：R744.8[医药卫生—神经病学与精神病学]