Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis  

作　　者：Xiang-Jun Li Chun-Yan Li Dan Bai Ying Leng 

机构地区：[1]Department of Ophthalmology,Affiliated Hospital of Beihua University,Jilin,Jilin Province,China [2]Department of Endocrinology,Affiliated Hospital of Beihua University,Jilin,Jilin Province,China

出　　处：《Neural Regeneration Research》2021年第1期172-178,共7页中国神经再生研究（英文版）

基　　金：This study was supported by the Natural Science Foundation of Jilin Province of China,No.20200201495JC;Jilin Province Health Technology Innovation Project,No.2017J089。

摘　　要：Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain unclear.In this study,we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years,which were included in the Web of Science Core Collection.We found the following:(1)a co-citation analysis of the references cited by all 552 articles indicated 15 clusters.In cluster#0,representing the stem cell field,some highly cited landmark studies emerged between 2009–2013.For example,endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars,in terms of their relationship and therapeutic prospects.Some researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells,using a variety of animal models of retinal vascular disease.All of these achievements provided references for the subsequent stem cell research.(2)An analysis of popular keywords among the 552 articles revealed that,during the past 20 years,a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was observed.The contents of these articles primarily involved the expression of vascular endothelial growth factor,vascular regeneration,oxidative stress,and inflammatory response.(3)A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012,including several studies addressing the expression of various growth factor genes;from 2014 to 2020,mouse models of diabetic retinopathy were recognized as mature animal models,and the most recent research has focused on macular degeneration,macular edema,neurodegeneration,and inflammatory changes in diabetic animal models.(4)Globally,the current authoritative studies have focused on basic r

关 键 词：DIABETES diabetic retinopathy epithelial cells MACULA progenitor cells RETINA stem cells visual analysis 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学] G353.1[医药卫生—临床医学]