巴雷特食管演变为食管腺癌的研究进展  

Reseach progress on development of Barrett esophagus to esophageal adenocarcinoma

作　　者：姚莉雯(综述)[1] 许树长(审校)[1] YAO Liwen;XU Shuchang(Department of Gastroenterology,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院消化科,上海200065

出　　处：《外科研究与新技术》2020年第2期100-104,共5页Surgical Research and New Technique

摘　　要：巴雷特食管(Barrett esophagus,BE)是指食管下段的正常复层鳞状上皮被化生的柱状上皮所取代。BE是食管腺癌(esophageal adenocarcinoma,EAC)的癌前病变。而从BE到EAC的演变和进展成为BE研究的焦点,诸多的关键信号因子及信号途径参与其中。本文就BE如何演变为EAC的研究进展作一综述。Barrett esophagus(BE)refers to the replacement of normal lamellar squamous epithelium in the lower esophagus by metaplasia of columnar epithelium.BE is the strongest risk for esophageal adenocarcinoma(EAC).The evolution and progression from BE to EAC has become the research focus of BE.Many key signaling factors and signaling pathways are involved.This paper reviewed the research progress on how BE evolves into EAC.

关 键 词：巴雷特食管 食管腺癌 发病机制 信号通路 

分 类 号：R735.1[医药卫生—肿瘤]