淋巴瘤患者血清肿瘤标志物检测的临床意义  

Clinical Significance of Serum Tumor Marker Detection in Lymphoma Patients

作　　者：潘明[1] 杨震[1] 胡安群[1] PAN Ming;YANG Zhen;HU An-qun(Anqing Municipal Hospital Laboratory Department,Anqing 246000,Anhui)

机构地区：[1]安徽省安庆市立医院检验科,安徽安庆246000

出　　处：《医学临床研究》2020年第7期1014-1016,共3页Journal of Clinical Research

摘　　要：【目的】探讨淋巴瘤患者血清肿瘤标志物检测的临床意义。【方法】选取本院收治的52例淋巴瘤患者为观察组(包括22例浸润者和30例未浸润者)。同时选取同期体检健康的志愿者52例为对照组。比较两组受试者以及浸润组和未浸润组患者血清铁蛋白(SF)、癌抗原15-3(CA15-3)、癌抗原125(CA125)及癌胚抗原(CEA)水平和细胞形态学,并进行临床特征分析。【结果】(1)观察组患者肿瘤标志物SF、CA15-3、CA125、CEA水平高于对照组,且差异均有显著性(P<0.05)。浸润组患者SF、CA15-3、CA125、CEA水平均高于未浸润组患者,且差异有显著性(P<0.05)。(2)血清SF、CA15-3、CA125、CEA与年龄、性别、白细胞计数(WBC)、血红蛋白(HGB)以及血小板计数(PLT)、淋巴细胞比例无相关性(P>0.05),血清CA15-3、CA125与幼稚淋巴细胞比例存在相关性(P<0.05),血清SF、CA15-3、CA125、CEA与淋巴瘤B症状存在相关性(P<0.05),血清SF及CA15-3水平与淋巴瘤分期存在相关性(P<0.05),血清SF、CA15-3及CA125与国际预后指标(IPI)存在相关性(P<0.05)。【结论】检测淋巴瘤患者血清肿瘤标志物有助于疾病的诊断、分期、预后评估,可为是否合并骨髓浸润提供可靠的参考依据,具有重要的临床意义。【Objective】To investigate the application of serum tumor markers combined with bone marrow morphometry in patients with lymphoma.【Methods】A total of 52 patients with lymphoma in our hospital were selected as the observation group(including 22 cases with tumor infiltration and 30 cases with non-infiltration).At the same time,52 healthy volunteers were selected as the control group.The levels of serum ferritin(SF),carcinoembryonic antigen 15-3(CA15-3),carcinoembryonic antigen 125(CA125),carcinoembryonic antigen(CEA),clinical data and cell morphology were compared between the two groups.【Results】(1)The levels of SF,CA15-3,CA125 and CEA in the observation group were higher than those in the control group(P<0.05).The levels of SF,CA15-3,CA125 and CEA in patients with tumor infiltration were higher than those with non-invasive infiltration(P<0.05).(2)Serum SF,CA15-3,CA125,CEA had no correlation with age,gender,WBC,HGB,PLT,lymphocyte proportion(P>0.05),while serum CA15-3,CA125 had correlation with infant lymphocyte proportion(P<0.05),serum SF,CA15-3,CA125,CEA had correlation with lymphoma B symptoms(P<0.05),serum SF and CA15-3 had correlation with lymphoma stage(P<0.05),serum SF,CA15-3 and CA125 were correlated with international prognostic index(IPI)(P<0.05).【Conclusion】Serum tumor markers combined with bone marrow morphometry can be helpful to the diagnosis,staging,and prognosis of lymphoma,and provide a reliable reference for the diagnosis of bone marrow infiltration.It has important clinical significance.

关 键 词：淋巴瘤/诊断 肿瘤标记 生物学 

分 类 号：R733.41[医药卫生—肿瘤]