奥扎格雷钠联合阿司匹林治疗急性脑梗死患者的疗效观察  

Effect of sodium ozagrel combined with aspirin on patients with cerebral infarction

作　　者：陈惠军 CHEN Hui-jun(Yuncheng County Hospital of Traditional Chinese Medicine,Heze 274700,China)

机构地区：[1]郓城县中医医院,274700

出　　处：《中国现代药物应用》2020年第15期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨奥扎格雷钠联合阿司匹林治疗急性脑梗死患者的疗效。方法78例急性脑梗死患者,根据治疗方案的不同分为联合组(43例)和单药组(35例)。两组患者均进行常规对症治疗,单药组患者服用阿司匹林肠溶片治疗,联合组患者在单药组基础上静脉滴注奥扎格雷钠治疗。比较两组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)评分及临床疗效;治疗前后脑动脉血流动力学参数[收缩期峰值流速(Vs)、平均血液流速(Vm)和脉动指数(PI)];治疗前后血小板相关参数[血小板计数(PLT)、平均血小板体积(MPV)以及血小板压积(PCT)]。结果治疗后,联合组的NIHSS评分(11.19±3.63)分明显低于单药组的(15.74±4.15)分,差异具有统计学意义(P<0.05)。联合组治疗后的临床疗效优于单药组,差异有统计学意义(P<0.05)。治疗后,联合组患者脑动脉Vs(89.65±7.06)cm/s、Vm(64.50±6.49)cm/s均高于单药组的(82.40±6.75)、(55.85±6.12)cm/s,PI(0.82±0.15)明显低于单药组的(0.94±0.23),差异均有统计学意义(P<0.05)。治疗后,联合组患者PLT(211.32±21.53)×10^9/L、PCT(0.21±0.03)%均高于单药组的(193.25±24.47)×10^9/L、(0.19±0.05)%,MPV(9.25±0.78)fl低于单药组的(9.84±0.76)fl,差异均有统计学意义(P<0.05)。结论奥扎格雷钠联合阿司匹林治疗急性脑梗死患者临床疗效较好,可显著降低患者NIHSS评分,改善脑部血流动力学和血小板参数。Objective To discuss the efficacy of sodium ozagrel combined with aspirin on patients with cerebral infarction.Methods A total of 78 patients with cerebral infarction were divided into combination group(43 cases)and single group(35 cases).Both groups received conventional symptomatic treatment.Single group was treated by aspirin enteric-coated tablets,and combination group was treated by intravenous drip of sodium ozagrel on the basis of single group.The National Institutes of Health stroke scale(NIHSS)score before and after treatment and clinical efficacy,hemodynamic parameters of cerebral artery[systolic velocity(Vs),mean velocity(Vm),pulsitility index(PI)],platelet related parameters[platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT)]before and after treatment were compared between the two groups.Results After treatment,NIHSS score(11.19±3.63)points of combination group was obviously lower than that of single group(15.74±4.15)points,and the difference was statistically significant(P<0.05).After treatment,the clinical efficacy of combination group was obviously better than that of single group,and the difference was statistically significant(P<0.05).After treatment,the cerebral artery Vs(89.65±7.06)cm/s and Vm(64.50±6.49)cm/s of combination group was obviously higher than that of single group(82.40±6.75)and(55.85±6.12)cm/s,PI(0.82±0.15)was obviously lower than that of single group(0.94±0.23),and the difference was statistically significant(P<0.05).After treatment,PLT(211.32±21.53)×10^9/L and PCT(0.21±0.03)%of combination group was obviously higher than that of single group(193.25±24.47)×10^9/L and(0.19±0.05)%,and MPV(9.25±0.78)fl was obviously lower than that of single group(9.84±0.76)fl,and the difference was statistically significant(P<0.05).Conclusion Sodium ozagrel combined with aspirin shows good clinical efficacy for patients with cerebral infarction,which can significantly lower NIHSS score,and improve cerebral hemodynamics and platelet parameters.

关 键 词：脑梗死 奥扎格雷钠 阿司匹林 脑部血流动力学 血小板 

分 类 号：R743.3[医药卫生—神经病学与精神病学]