外泌体在乳腺癌侵袭转移及耐药中的研究进展  

Research progress on the role of exosomes in metastases and drug resistance of breast cancer

作　　者：刘巧园 陆永奎[1] 谢伟敏[1] 段丽霞 刘燕[1] Liu Qiaoyuan;Lu Yongkui;Xie Weimin;Duan Lixia;Liu Yan(Department of Breast,the Affiliated Cancer Hospital of Guangxi Medical University,Guangxi 530021)

机构地区：[1]广西医科大学附属肿瘤医院乳腺肿瘤内科,南宁530021

出　　处：《广西医科大学学报》2020年第7期1371-1374,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金地区科学基金资助项目(No.81560468);国家自然科学青年基金资助项目(No.81602315);广西医疗卫生适宜技术开发与推广应用资助项目(No.S201635);广西壮族自治区卫生厅资助项目(No.Z2013428)。

摘　　要：外泌体是一种由许多细胞分泌到细胞外的微小囊泡,可介导细胞间的物质交换和信息交流,是近年来肿瘤研究的热点之一。外泌体与乳腺癌的发生发展密切相关,并通过分泌各种信号分子,促进乳腺癌细胞上皮间质转化和迁移、肿瘤血管生成、肿瘤侵袭转移,并且参与耐药的形成。本文将对外泌体在乳腺癌侵袭转移及耐药中的机制进行综述。Exosomes are small vesicles secreted by varioustypes of cells to the outside of the cells,it can mediate material exchange and information exchange between cells,which is one of the hot spots in tumor research in recent years.Exosomes are closely related to the development and progression of breast cancer,and through the secretion of various signal molecules, they promote the epithelialmesenchymaltransition and migration of breast cancer cells, enhance tumor angiogenesis,promote tumor invasion and metastasis,and participate in the formation of drug resistance.In this paper,we discuss the research progressof exosomes in breast cancer invasion, metastasis and resistance.

关 键 词：外泌体 乳腺癌 转移 耐药 

分 类 号：R737.9[医药卫生—肿瘤]