益气清热方联合辛复宁治疗宫颈高危型HPV持续性感染的临床观察  

Clinical observation of Yiqi Qingre Recipe combined with Xinfuning in the treatment of cervical high-risk HPV persistent infection

作　　者：覃晓洵 钱麟[1] 杨红[1] 赵睿男 马函琳 金铭歆 QIN Xiaoxun;QIAN Lin;YANG Hong;ZHAO Ruinan;MA Hanlin;JIN Mingxin(Department of Gynaecology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院妇科,上海201203

出　　处：《上海中医药大学学报》2020年第4期15-20,共6页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市科委科研计划项目(18401904200)。

摘　　要：目的:观察益气清热方口服联合辛复宁阴道给药治疗宫颈高危型人乳头瘤病毒(HPV)持续性感染的临床疗效。方法:纳入74例气阴两虚兼湿热下注证宫颈高危型HPV持续性感染患者,随机分为治疗组和对照组,每组各37例。治疗组患者予益气清热方口服联合辛复宁阴道给药治疗,对照组患者予辛复宁阴道给药治疗,疗程为3个月经周期。比较两组患者的HPV转阴率、中医证候疗效及湿热下注证、气阴两虚证证候积分的变化。结果:治疗后,治疗组患者的HPV转阴率为65.4%、对照组为42.2%,治疗组的HPV转阴率高于对照组(P<0.05);治疗后,治疗组患者的宫颈HPV18分型转阴率高于对照组(P<0.05),其余分型HPV转阴率组间比较差异均无统计学意义(P>0.05)。治疗后,治疗组患者的中医证候疗效总有效率为81.1%、对照组为56.8%,治疗组疗效优于对照组(P<0.01);两组患者的湿热下注证、气阴两虚证中医证候积分较治疗前均显著降低(P<0.01),且治疗组患者的气阴两虚证证候积分明显低于对照组(P<0.01)。结论:益气清热方口服联合辛复宁阴道给药治疗宫颈高危型HPV持续性感染,可有效提高宫颈HPV转阴率,显著改善患者的中医证候,尤其是气阴两虚证候,值得在临床中推广。Objective:To observe the clinical efficacy of Yiqi Qingre Recipe by oral administration combined with Xinfuning by intravaginal administration in the treatment of cervical high-risk human papilloma virus(HPV)persistent infection.Methods:Seventy-four patients of cervical high-risk HPV persistent infection with syndrome of deficiency of both qi and yin and syndrome of dampness-heat diffused downward were included and randomly divided into the treatment group and control group,37 cases in each group.The patients in the treatment group were orally treated with Yiqi Qingre Recipe combined with Xinfuning by intravaginal administration,and the patients in the control group were treated with Xinfuning by intravaginal administration.The treatment course was 3 menstrual cycles.The negative conversion rate of HPV,the efficacy of Chinese medical syndrome and the scores of syndrome of deficiency of both qi and yin as well as syndrome of dampness-heat diffused downward were compared between the two groups.Results:After treatment,the negative conversion rates of HPV in the treatment group and the control group were 65.4%and 42.2%respectively,and the negative conversion rate of HPV in the treatment group was higher than that in the control group(P<0.05);after treatment,the negative conversion rate of cervical HPV18 type in the treatment group was higher than that in the control group(P<0.05),and there were no statistically significant differences in the negative conversion rates of other HPV types between the two groups(P>0.05).After treatment,the total effective rates of Chinese medical syndrome in the treatment group and the control group were 81.1%and 56.8%respectively,and the efficacy of the treatment group was better than that of the control group(P<0.01);the scores of syndrome of deficiency of both qi and yin as well as syndrome of dampness-heat diffused downward were significantly decreased in both groups compared with those before treatment(P<0.01),and the score of syndrome of deficiency of both qi and yin in the treatme

关 键 词：人乳头瘤病毒(HPV) 益气清热方 重组人干扰素 气阴两虚 湿热下注 中西医结合 

分 类 号：R737.33[医药卫生—肿瘤]