胫骨横向骨搬移技术促进微循环再生及组织修复生物学机制的初步探索  

Biological mechanisms of tibial transverse transport for promoting microcirculation and tissue repair

作　　者：杨永康 李刚[1] YANG Yongkang;LI Gang(Department of Orthopaedics&Traumatology,Faculty of Medicine,the Chinese University of Hong Kong,Hong Kong,P.R.China)

机构地区：[1]香港中文大学医学院矫形外科及创伤学系,中国香港特别行政区

出　　处：《中国修复重建外科杂志》2020年第8期964-968,共5页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的探讨胫骨横向骨搬移(tibial transverse transport,TTT)技术促进微循环再生及组织修复的生物学机制。方法回顾性总结TTT技术临床应用及动物模型的研究。结果TTT技术促进微血管网重建可能的生物学机制:①胫骨开窗降低髓内压力,改善微循环;②张应力刺激促进毛细血管再生,加速新生"跨皮质血管"网的形成;③全身干细胞的调动,调解局部炎症反应等。结论临床研究已证实TTT技术对于下肢缺血和糖尿病足溃疡有明显疗效,手术创面较小、易于操作,且不会对骨骼形态造成不良影响,具有较好的应用前景。但TTT技术的生物学机制仍需进一步研究明确。Objective To explore the biological mechanisms of tibial transverse transport(TTT)for promoting microcirculation and tissue repair.Methods The clinical application and animal model study of TTT were reviewed.Results The possible biological mechanisms of TTT for promoting microvascular network formation and tissue repair:①Tibial corticotomy reduces intramedullary pressure and improves microcirculation;②Tension stress stimulation promotes microvascular regeneration and accelerates the formation of new"transcortical vessels"network;③Systemic mobilization of stem cells,mediating local inflammation,etc.Conclusion TTT has been clinically proven to be effective for the management of lower limb ischemia and diabetic foot ulcers.The surgical procedure is relatively easy with little adverse effects on bone structures.The TTT has good application prospects despite the biological mechanisms of which still need further exploration.

关 键 词：胫骨横向骨搬移技术 微循环 组织修复 生物学机制 

分 类 号：R687.3[医药卫生—骨科学]