食欲抑制剂孕甾皂苷P57和果同尼皂苷F的研究进展  

Advances in Research on Appetite-suppressant Pregnane Saponins P57 and Gordonoside F

作　　者：李国龙 李微 LI Guolong;LI Wei(Department of Medicinal Chemistry,School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院药物化学系,江苏南京211198

出　　处：《药学进展》2020年第7期535-545,共11页Progress in Pharmaceutical Sciences

摘　　要：P57和果同尼皂苷F是从南非火地亚仙人掌中分离得到的孕甾皂苷类化合物,具有抑制食欲的活性。主要针对P57和果同尼皂苷F的化学合成、生物活性和作用机制研究进行综述,旨在为相关的健康产品和药物研发提供参考。P57 and Gordonoside F are pregnane saponins isolated from a South African cactus-like Hoodia gordonii with appetitesuppressive activity.This article reviews the advances in research on the chemical synthesis,biological activities and action mechanisms of P57 and Gordonoside F,so as to provide some reference for the development of relevant health products and drugs.

关 键 词：火地亚 肥胖治疗 食欲抑制剂 P57 果同尼皂苷F 

分 类 号：R914.5[医药卫生—药物化学]