血清胆红素对肺癌患者病情发生发展的影响  

The influence of serum bilirubin on the occurrence and development of lung cancer patients

作　　者：郑辉[1] 杨焦峰[2] 王伟娟[1] ZHENG Hui;YANG Jiaofeng;WANG Weijuan(Department of Clinical Laboratory,The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China;Department of Clinical Laboratory,The Second Affiliated Hospital of Xinxiang Medical College,Xinxiang 453002,China)

机构地区：[1]新乡医学院第三附属医院检验科,河南新乡453003 [2]新乡医学院第二附属医院检验科,河南新乡453002

出　　处：《河南大学学报（医学版）》2020年第4期266-269,共4页Journal of Henan University:Medical Science

基　　金：河南省高等学校重点科研项目计划(16A310010);新乡医学院博士启动基金(5051220)。

摘　　要：〔目的〕探索血清胆红素对肺癌患者病情发生发展的影响。〔方法〕选取2016年3月至2019年5月于某医院接受治疗的398例肺癌患者为观察组,另选取同期于该院接受体检的396例健康人为对照组。按照肺癌TNM分期将观察组患者分为T1组(71例)、T2组(146例)、T3组(94例)、T4组(87例)。检测并比较观察组与对照组的总胆红素水平、超氧化物歧化酶水平及丙二醛水平,比较各肺癌分期患者与对照组的胆红素水平、超氧化物歧化酶水平及丙二醛水平。〔结果〕观察组的总胆红素水平(12.48±3.56)μmol/L、结合胆红素水平(3.12±0.46)μmol/L、未结合胆红素水平(10.35±3.04)μmol/L、超氧化物歧化酶水平(117.27±16.04)U/mL,显著高于对照组,数据的比较在统计学上有显著性(P<0.05)。观察组丙二醛水平(4.26±0.24)nmol/mL,显著低于对照组,数据的比较在统计学上有显著性(P<0.05)。T3组和T4组患者的总胆红素和未结合胆红素水平显著低于对照组,数据的比较在统计学上有显著性(P<0.05)。T2组、T3组、T4组患者的结合胆红素水平显著低于对照组,数据的比较在统计学上有显著性(P<0.05)。T1组、T2组、T3组、T4组的超氧化物歧化酶水平显著低于对照组,数据的比较在统计学上有显著性(P<0.05)。T1组、T2组、T3组、T4组患者的丙二醛水平显著高于对照组,数据的比较在统计学上有显著性(P<0.05)。〔结论〕机体抗氧化与肺癌的发生机制有关,血清胆红素是影响该过程的关键因素,对于肺癌患者病情发展具有预示作用。低水平血清胆红素显著提高了肺癌的发生率,加重患者的病情恶化程度,临床医务人员在治疗过程中应注重血清胆红素水平的变化并提高其水平。〔Objective〕To explore the effect of serum bilirubin on the occurrence and development of lung cancer patients.〔Methods〕398 patients with lung cancer treated in our hospital from March 2016 to May 2019 were selected as observation group,and 396 healthy persons who were willing to undergo health checkup during the same period were selected as control group.According to TNM stage of lung cancer,71 patients in the observation group were divided into T1 group,146 patients in T2 group,94 patients in T3 group and 87 patients in T4 group.The levels of total bilirubin,superoxide dismutase(SOD)and malondialdehyde(MDA)were measured and compared between the two groups.〔Results〕Observation group patients total bilirubin(12.48±3.56)μmol/L,bound bilirubin(3.12±0.46)μmol/L,unbound bilirubin(10.35±3.04)μmol/L,superoxide dismutase(117.27±16.04)U/mL level was significantly higher than those of the control group,and the comparison of data was statistically significant(P<0.05).The malondialdehyde(4.26±0.24)nmol/mL level of the observation group was significantly lower than that of the control group,and the comparison of data was statistically significant(P<0.05).The total bilirubin and unbound bilirubin levels in the T3 and T4 groups were significantly lower than those in the control group,and the comparison of data was statistically significant(P<0.05).The combined bilirubin levels of patients in the T2,T3,and T4 groups were significantly lower than those in the control group,and the comparison of data was statistically significant(P<0.05).The levels of superoxide dismutase in the T1 group,T2 group,T3 group,and T4 group were significantly lower than that in the control group,and the comparison of data was statistically significant(P<0.05).The levels of malondialdehyde in the T1,T2,T3,and T4 groups were significantly higher than that in the control group,and the comparison of data was statistically significant(P<0.05).〔Conclusion〕Antioxidant activity is related to the pathogenesis of lung cancer.Serum bilirubi

关 键 词：血清胆红素 肺癌 病情发展 未结合胆红素 

分 类 号：R734.2[医药卫生—肿瘤]