利奈唑胺致黑毛舌  

Black hairy tongue due to linezolid

作　　者：沈江华[1] 于雅卉 宋浩鑫 褚燕琦[1] Shen Jianghua;Yu Yahui;Song Haoxin;Chu Yanqi(Department of Pharmacy,Xuanwu Hospital,Capital Medical University,National Clinical Research Center for Geriatric Disorders,Beijing 100053,China;School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China;Department of Pharmacy,Beijing Fengtai Hospital of Integrated Tradi-tional and Western Medicine,Beijing 100072,China)

机构地区：[1]首都医科大学宣武医院药剂科/国家老年疾病临床医学研究中心,北京100053 [2]首都医科大学药学院,北京100069 [3]北京市丰台中西医结合医院药剂科,100072

出　　处：《药物不良反应杂志》2020年第7期432-434,共3页Adverse Drug Reactions Journal

摘　　要：1例83岁男性患者因颈椎融合术后手术切口感染,给予利奈唑胺600 mg、1次/12 h静脉滴注,亚胺培南西司他丁钠1 g、1次/8 h静脉滴注。3 d后根据药敏试验结果停用亚胺培南西司他丁钠,继续利奈唑胺治疗。使用利奈唑胺2周后,患者诉口干和舌部感觉异常;18 d后出现舌部中央舌苔颜色发黑,大量饮水后不缓解,此后逐渐出现牙根变黑、义齿色素沉着。考虑为黑毛舌,与利奈唑胺有关。停用利奈唑胺,给予复方氯己定含漱液漱口。12 d后患者舌苔恢复正常,口干、口渴现象消失,牙根颜色变浅。An 83-year-old male patient received IV infusions of linezolid 600 mg once per 12 hours and imipenem and cilastatin sodium 1 g once per 8 hours for incisional wound infection after cervical spinal fusion.Three days later,imipenem and cilastatin sodium was stopped according to the drug sensitive test result and linezolid was continued.Two weeks after the use of linezolid,the patient developed dry mouth,and abnormal sensation of tongue;and 18 days later,he developed black tongue coating in the center of the tongue,which could not relieved after drinking a lot of water.After that,the tooth root blackened and the denture pigmented gradually.It was considered as black hairy tongue,which might be associated with linezolid.Linezolid was stopped and compound chlorhexidine gargle was given for gargling.Twelve days later,the patient′s tongue coating returned to normal,the symptoms of dry mouth and thirst disappeared,and the color of tooth root became lighter.

关 键 词：利奈唑胺 舌疾病 舌 毛苔 

分 类 号：R781.57[医药卫生—口腔医学]