血管性痴呆患者认知功能改变与腔隙性脑梗死、脑白质病变的相关性研究  

Relevant Research of Cognitive Function Change with Lacunar Infarction and Leukodystrophy of Patients with Vascular Dementia

作　　者：王宇[1] 侯英宇[1] 崔丽波[1] Wang Yu;Hou Yingyu;Cui Libo(Heilongjiang Armed Police Corps Hospital, Harbin 150076, China)

机构地区：[1]武警黑龙江省总队医院,哈尔滨150076

出　　处：《黑龙江科学》2020年第16期52-53,共2页Heilongjiang Science

摘　　要：分析血管性痴呆患者认知功能改变与腔隙性脑梗死、脑白质病变的相关性。随机选择2019年5月—2020年4月在武警黑龙江省总队医院接受血管性痴呆治疗的70例患者,应用简易精神状态量表与蒙特利尔认知评估量表进行评估,结合脑白质病变程度对患者进行分级处理,比较不同分级脑白质病变患者的MMSE评分、MoCA评分和不同腔梗数目患者的MMSE评分、MoCA评分,并分析血管性痴呆患者认知功能改变与腔隙性脑梗死、脑白质病变的相关性。结果表明,脑白质病变评分:1级32例,2级23例,3级15例。不同分级脑白质病变患者的MMSE评分、MoCA评分有显著的差异。1级脑白质病变患者的MMSE评分为(17.35±2.87)分、MoCA评分为(24.21±3.12)分;2级脑白质病变患者的MMSE评分为(14.46±2.32)分、MoCA评分为(20.45±2.73)分;3级脑白质病变患者的MMSE评分为(12.02±2.09)分、MoCA评分为(16.96±2.35)分,差异有统计学意义(t=6.3445,P<0.05)。多发腔梗30例,MMSE评分为(13.08±2.77)分、MoCA评分为(19.42±2.65)分;单发腔梗40例,MMSE评分为(16.23±3.34)分、MoCA评分为(23.23±2.34)分,前后比较差异显著(t=5.6576,P<0.05)。血管性痴呆患者的认知功能和脑白质病变程度以及腔梗数目有很大的关联(P<0.05),均呈负比例。血管性痴呆患者认知功能改变与腔隙性脑梗死、脑白质病变息息相关,临床治疗中应给予高度重视。The paper analyzed the relevance of cognitive function change with lacunar infarction and leukodystrophy of patients with vascular dementia.70 patients with vascular dementia in Heilongjiang Armed Police Corps Hospital from May,2019 to April,2020 were randomly selected.Simple psychosis scale and Montreal cognition evaluation scale were used to evaluate,and patients were staged care with leukodystrophy degrees.MMSE score and MoCA score of different numbers of lacunar infarction,and of patients with different leukodystrophy degrees were compared.Relevance of cognitive function change with lacunar infarction and leukodystrophy of patients with vascular dementia was analyzed.In leukodystrophy score,there was 32 patients of grade 1,23 patients of grade 2,and 15 patients of grade 3.There was statistically significant difference of MMSE score and MoCA score of patients with different grades of leukodystrophy.MMSE score and MoCA score of patients with leukodystrophy of grade 1 were(17.35±2.87)and(24.21±3.12).Those of grade 2 were(14.46±2.32)and(20.45±2.73).Those of grade 3 were(12.02±2.09)and(16.96±2.35).There was statistically significant difference(t=6.3445,P<0.05).There were 30 patients with multi lacunar infarction,and MMSE score and MoCA score were(13.08±2.77)and(19.42±2.65).There were 40 patients with single lacunar infarction,and MMSE score and MoCA score were(16.23±3.34)and(23.23±2.34).There was statistically significant difference(t=5.6576,P<0.05).There was great relevance of cognitive function with leudodystrophy degree and lacunar infarction numbers of patients with vascular dementia(P<0.05),with negative ratio.There was close relationship of cognitive function change with lacunar infarction and leukodystrophy of patients with vascular dementia,so we should pay great attention to it in clinical treatment.

关 键 词：血管性痴呆 脑白质病变 腔隙性脑梗死 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]