替罗非班治疗急性期脑梗死效果分析  

Analysis of tirofiban in the treatment of acute stage of cerebral infarction

作　　者：叶端玲 许文勇[1] 陈琳[1] 何方方 YE Duanling;XU Wenyong;CHEN Lin;HE Fangfang(Xiamen Third Hospital Affiliated to Fujian University of traditional Chinese Medicine,Xiamen 361100,China)

机构地区：[1]福建中医药大学附属厦门第三医院,福建厦门361100

出　　处：《中国实用神经疾病杂志》2020年第16期1424-1428,共5页Chinese Journal of Practical Nervous Diseases

基　　金：厦门市医疗卫生项目(编号:3502Z20189042);福建中医药大学校管课题(编号:XB2019125)。

摘　　要：目的观察替罗非班在脑梗死急性期患者抗血小板治疗中的效果。方法选取168例急性脑梗死患者,对照组采用双联抗血小板治疗,观察组使用替罗非班治疗,治疗前、治疗后24 h、48 h及出院时使用NIHSS对2组患者神经缺损功能情况进行评估。结果观察组治疗前NIHSS评分与对照组比较差异无统计学意义(P>0.05);观察组治疗后24 h、48 h NIHSS评分与对照组比较,差异均有统计学意义(P<0.05)。观察组平均住院时间小于对照组,但两者差异无统计学意义(P>0.05)。结论替罗非班在脑梗死急性期患者的应用效果优于单纯阿司匹林及硫酸氢氯吡格雷双联抗血小板治疗,能有效改善脑梗死患者急性期的神经功能缺损,还可能缩短患者住院时间。Objective To compare the efficacy of tirofiban in antiplatelet therapy in patients with acute cerebral infarction.Methods 168 patients with acute cerebral infarction were treated from January 2017 to February 2019,the control group was treated with double antiplatelet therapy,the observation group was treated with tirofiban,and National Institutes of Health stroke scale(NIHSS)was used to evaluation and comparison with neurological deficit function before the patient was admitted to hospital without any medication,24 hours and 48 hours used medication after admission in the two groups.Results There was no significant difference in NIHSS scores between the observation group and the control group without medication(P>0.05).There were statistical differences between the observation group and the control group with 24 hours and 48 hours after medication(P<0.05),and the NIHSS scores of the observation group were lower than those of the control group.The average hospitalization time of the observation group was less than that of the control group,but there were not statistical differences.Conclusion The therapeutic effect of tirofiban in patients with acute cerebral infarction is better than that of aspirin and clopidogrel sulfate combined with antiplatelet therapy,and tirofiban can effectively improve the neurological deficit in patients with acute cerebral infarction and may also shorten the hospital stay.

关 键 词：脑梗死 替罗非班 急性期 NIHSS评分 抗血小板治疗 阿司匹林 硫酸氢氯吡格雷 

分 类 号：R743.33[医药卫生—神经病学与精神病学]