多塞平治疗脑卒中后抑郁状态及对神经功能缺损的康复影响  

Doxepin in the Treatment of Post-stroke Depression and Its Effect on Rehabilitation of Neurological Deficits

作　　者：李鹏 李爱歆[2] LI Peng;LI Ai-xin(Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China;Department of Cardiology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院神经内科,黑龙江佳木斯154002 [2]佳木斯大学附属第一医院心内科,黑龙江佳木斯154002

出　　处：《医学信息》2020年第15期142-143,共2页Journal of Medical Information

基　　金：黑龙江省卫生计生委科研课题(编号:2017-382)。

摘　　要：目的研究多塞平治疗脑卒中后抑郁临床效果及对神经功能缺损康复的影响。方法选取2017年6月~2019年6月在我院诊治的72例脑卒中后抑郁患者为研究对象,采用随机数字表法分为对照组和观察组,各36例。对照组采用常规治疗,观察组在常规治疗基础上加服多赛平。比较两组临床治疗疗效、治疗前后汉密尔顿抑郁评分(HAMD)和神经功能缺损评分、生活自理能力评分以及不良反应发生情况。结果观察组临床治疗总有效率(94.44%)高于对照组(80.56%)(P<0.05);治疗后两组HAMD评分、神经功能缺损评分均低于治疗前,且观察组低于对照组(P<0.05);治疗后两组生活自理能力评分均高于治疗前,且观察组高于对照组(P<0.05);观察组不良反应发生率(11.11%)与对照组(8.33%)比较,差异无统计学意义(P>0.05)。结论多塞平治疗脑卒中后抑郁状态疗效确切,可减轻患者抑郁状态,促进患者神经功能恢复,进一步提高其生活自理能力,且不会增加不良反应,用药安全可靠。Objective To study the clinical effect of doxepin in the treatment of post-stroke depression and its influence on the rehabilitation of neurological deficits.Methods A total of 72 patients with post-stroke depression who were diagnosed and treated in our hospital from June 2017 to June 2019 were selected as the research objects.They were divided into a control group and an observation group using a random number table method,with 36 cases in each group.The control group received conventional treatment,and the observation group received doxepin on the basis of conventional treatment.The clinical treatment efficacy,Hamilton Depression Score(HAMD),neurological deficit score,self-care ability score,and adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the observation group(94.44%)was higher than that of the control group(80.56%)(P<0.05);the HAMD scores and neurological deficit scores of the two groups after treatment were lower than those before treatment,and the observation group was lower than the control group(P<0.05);After treatment,the scores of self-care ability of the two groups were higher than before treatment,and the observation group was higher than the control group(P<0.05);the incidence of adverse reactions in the observation group(11.11%)was compared with the control group(8.33%),the difference was not statistically significant(P>0.05).Conclusion Doxepin has a definite effect in treating post-stroke depression.It can alleviate the patient's depression,promote the recovery of the patient's neurological function,and further improve their ability to take care of themselves without increasing adverse reactions.The medication is safe and reliable.

关 键 词：多塞平 脑卒中后抑郁 神经功能缺损 康复 

分 类 号：R749.1[医药卫生—神经病学与精神病学]