2型糖尿病患者血清二肽基肽酶4水平与颈动脉粥样硬化的关系  

The relationship between serum levels of dipeptydil peptidase-4 and carotid artery atherosclerosis in type 2 diabetes

作　　者：王本孝[1] 王俊珺[1] 王鹏[1] 刘建魁[1] WANG Benxiao;WANG Junjun;WANG Peng;LIU Jiankui(Department of Neurology,General Hospital of Wan-bei Coal and Electricity Group,the Third Hospital Affiliated of Bengbu Medical College,SuzhouAnhui 234011,China;不详)

机构地区：[1]皖北煤电集团总医院,蚌埠医学院第三附属医院神经内科,234011

出　　处：《中国神经免疫学和神经病学杂志》2020年第4期309-311,325,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：蚌埠医学院自然科学基金项目(BYKY16171)。

摘　　要：目的探讨2型糖尿病患者外周血中二肽基肽酶4(DPP4)水平与颈动脉粥样硬化之间的关系。方法应用彩色多普勒超声检查颈动脉,根据颈动脉内中膜厚度(IMT)将86例糖尿病患者分为IMT<0.9 mm组(16例)、0.9 mm≤IMT<1.3 mm组(28例)和IMT≥1.3 mm组(42例),同时选取同期住院非糖尿病患者32例为对照,采用酶联免疫吸附试验方法检测各组外周血清DPP4水平。结果糖尿病组血清DPP4水平高于对照组〔(5.194±1.397)mg/L比(3.690±1.428)mg/L,P<0.05〕;糖尿病IMT≥1.3 mm组血清DPP4水高于IMT<0.9 mm组〔(6.060±1.454)mg/L比(4.300±1.200)mg/L,P<0.01〕与0.9 mm≤IMT<1.3 mm组〔(6.060±1.454)mg/L比(5.851±0.608)mg/L,P<0.01〕;0.9 mm≤IMT<1.3 mm组亦显著高于IMT<0.9 mm组〔(5.851±0.608)mg/L比(4.300±1.200)mg/L,P<0.05〕。线性相关分析结果显示糖尿病组患者IMT与血清DPP4水平成正相关性(r=1.242,P<0.05)。结论糖尿病患者血清DPP4水平与颈动脉IMT成正相关。DPP4水平可能反映了动脉粥样硬化的程度。Objective To investigate the relationship between serum levels of dipeptydil peptidase-4(DPP4)and carotid artery atherosclerosis in type 2 diabetes.Methods Carotid artery intima-media thickness(IMT)was examined by carotid ultrasonography and the levels of serum DPP4 was measured by enzyme immunoassay in 86 patients with type 2 diabetes and 32 non-diabetic patients who were admitted in the same period.Patients with type 2 diabetes were divided into an IMT<0.9 mm group(16 cases),a 0.9 mm≤IMT<1.3 mm group(28 cases),and an IMT≥1.3 mm group(42 cases)according to their carotid artery sonography results.The serum level of DPP4 was compared among different groups.Results The serum level of DPP4 in the type 2 diabetes group was significantly higher than that of the normal control group[(5.194±1.397)mg/L vs.(3.690±1.428)mg/L,P<0.05].Among patients with type 2 diabetes,the serum level of DPP4 in the IMT≥1.3 mm group was significantly higher than those of the IMT<0.9 mm group[(6.060±1.454)mg/L vs.(4.300±1.200)mg/L,P<0.01]and the 0.9 mm≤IMT<1.3 group[(6.060±1.454)mg/L vs.(5.851±0.608)mg/L,P<0.01],the later was significantly higher than the IMT<0.9 mm group[(5.851±0.608)mg/L vs.(4.300±1.200)mg/L,P<0.05].Linear correlation analysis showed that serum level of DPP4 was positive correlated with IMT(r=1.242,P<0.05)in patients with type 2 diabetes.Conclusions There was a positive correlation between the serum level of DPP4 and carotid IMT in diabetic patients.The serum level of DPP4 may be a potential marker of carotid atherosclerosis in diabetes.

关 键 词：2型糖尿病 二肽基肽酶4 颈动脉内中膜厚度 

分 类 号：R743.9[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]