多靶点分子对接研究艾叶抗乙肝病毒的有效成分  

Study on Anti-HBV Active Components of Artemisia Argyi by Multi-target Molecular Docking

作　　者：王卫京[1] 詹世平[1] 丁仕强[1] Wang Wei-jing;Zhan Shi-ping;Ding Shi-qiang

机构地区：[1]大连大学环境与化学工程学院,辽宁大连116622

出　　处：《化工设计通讯》2020年第9期157-159,共3页Chemical Engineering Design Communications

摘　　要：中药治乙肝的历史十分悠久。以乙肝核衣壳蛋白,聚合酶以及HBx蛋白为靶点,用分子对接软件iGEMDOCK和Ledock对艾叶组分进行了研究。结果表明,艾叶组分对HBx蛋白的抑制作用较强,对核衣壳蛋白和聚合酶抑制作用较弱。在艾叶中,多种组分对靶点蛋白有抑制作用,其中quercetin对三个靶点均有较强的抑制作用。Chinese medicine has a long history of treating Hepatitis B.In this paper,the components of Artemisia Argyi were studied by using molecular docking software IGEMDOCK and Ledock,targeting the HBV core protein,polymerase and HBx protein.The results show that the components of Artemisia Argyi have stronger inhibitory effect on HBx protein and weaker inhibitory effect on core protein and polymerase.In the Artemisia Argyi,the target proteins are inhibited by various components,and Quercetin has strong inhibition on all three targets.

关 键 词：艾叶 分子对接 乙肝病毒 

分 类 号：R932[医药卫生—生药学]