肝癌衍生生长因子在胶质瘤中的作用及研究进展  

The role and research progress of hepatoma-derived growth factor in glioma

作　　者：罗起胜[1] 黄腾月 燕鹏 龚举鑫 黄海能[1] 罗琨祥[1] 郑传华 杨少春[2] Luo Qisheng;Huang Tengyue;Yan Peng;Gong Juxin;Huang Haineng;Luo Kunxiang;Zheng Chuanhua;Yang Shaochun(Department of Neurosurgery,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;Department of Neurosurgery,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)

机构地区：[1]右江民族医学院附属医院神经外科,广西百色533000 [2]赣南医学院第一附属医院神经外科,赣州341000

出　　处：《中华实验外科杂志》2020年第6期1175-1178,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81760450);广西自然科学基金(面上项目:2017GXNSFAA198322,重点项目:2019GXNSFDA245034)。

摘　　要：肝癌衍生生长因子(HDGF)是具有多功能的一种特殊蛋白,可作为生长、血管生成因子和抗凋亡因子以及抗癌治疗的潜在靶分子,参与各种恶性疾病的发生和发展过程,由于HDGF与许多恶性肿瘤的生长及进展有着紧密联系,在临床上可作为肿瘤患者的进展潜在标志物,其表达水平可作为一个独立的预后因素,用于预测包括神经胶质瘤在内的各种恶性肿瘤患者的无疾病生存期和总体存活率。本文概述了HDGF的特征,并描述了HDGF作为胶质瘤血管生成因子的潜在作用,为临床胶质瘤的精准诊疗以及作为预后标志物提供依据和参考。Hepatoma-derived growth factor(HDGF)is a unique and multifunctional protein that can be used as a potential target for growth,angiogenesis and anti-apoptotic factors and anti-cancer therapy,and participates in the development and progression of various malignant diseases.Because HDGF is closely related to the growth and progression of many malignant tumors,it can be used as a potential marker for the progression of cancer patients.The expression level of this gene can be used as an independent prognostic factor for predicting disease-free survival and overall survival in patients with various malignancies,including gliomas.This article outlines the characteristics of HDGF and describes the potential role of HDGF as a glioma angiogenesis factor,which provides evidence and reference for the accurate diagnosis and treatment of clinical gliomas and as a prognostic marker.

关 键 词：肝癌衍生生长因子 胶质瘤 血管生成因子 靶向治疗 

分 类 号：R739.41[医药卫生—肿瘤]