预防使用抗真菌药物对增加肝衰竭患者生存率的疗效分析  

The effect of antifungal drugs on the survival rate of patients with liver failure

作　　者：郭婷[1] 李清奇 王伟新[1] Guo Ting;Li Qingqi;Wang Weixin(Department of Infectious Disease,The Second Affiliated Hospital of Yichun University,Yichun,Jiangxi,336000,China)

机构地区：[1]宜春学院第二附属医院感染科,江西宜春336000

出　　处：《当代医学》2020年第24期56-58,共3页Contemporary Medicine

基　　金：宜春市科技局科技计划项目(JXYC2019KSA021)。

摘　　要：目的探讨预防使用抗真菌药物对增加肝衰竭患者生存率的疗效。方法选取2013年1月至2019年5月本院收治的25~65岁的肝衰竭患者50例,采用随机分配法分为对照组(n=34)和实验组(n=16)。对照组患者给予核苷类药物抗病毒、还原性谷胱甘肽、甘草酸制剂、血浆、白蛋白、肠道菌群调节剂、激素或人工肝治疗。实验组患者在对照组基础上加用氟康唑或者伏立康唑进行预防抗真菌治疗。对比两组患者侵袭性真菌感染(IFI)发生率、生存率、住院时间及并发症发生情况。结果实验组IFI发生率为6.25%,明显低于对照组的32.35%(P<0.05);实验组平均住院时间明显短于对照组,实验组生存率明显高于对照组,差异有统计学意义(P<0.05)。实验组发生低钾血症5例,胃肠道反应2例。结论肝衰竭患者中预防使用抗真菌药物可有效减少真菌感染的发生,改善疾病预后,延长患者的生存周期。Objective To explore the effect of antifungal drugs on the survival rate of patients with liver failure.Methods From January 2013 to May 2019,50 patients with liver failure aged 25 to 65 years in our hospital were divided into control group(n=34)and experimental group(n=16).The patients in the control group were given antiviral nucleoside drugs,reduced glutathione,glycyrrhizic acid preparation,plasma,albumin,intestinal flora regulator,hormone or artificial liver treatment.The patients in the experimental group were treated with fluconazole or voriconazole on the basis of the control group.The incidence,survival rate,length of stay and complications of invasive fungal infection(IFI)were compared between the two groups.Results The incidence of IFI in the experimental group was 6.25%,which was significantly lower than 32.35%in the control group(P<0.05),the average hospitalization time in the experimental group was significantly shorter than that in the control group,and the survival rate in the experimental group was significantly higher than that in the control group(P<0.05).Hypokalemia occurred in 5 cases and gastrointestinal reaction in 2 cases in the experimental group.Conclusion The use of antifungal drugs in the prevention of liver failure can effectively reduce the incidence of fungal infection,improve the prognosis of the disease,and prolong the life cycle of patients.

关 键 词：肝衰竭 真菌感染 抗菌药物 生存率 

分 类 号：R575.3[医药卫生—消化系统]