门电压法调控纳米孔分辨率  

Regulation of nanopore resolution by gate voltage method

作　　者：王彬 吕海生[1] 伍根生 马冬琴 宋福磊 WANG Bin;LU Haisheng;WU Gensheng;MA Dongqin;SONG Fulei(School of Mechanical and Electronic Engineering,Nanjing Forestry University,Nanjing 210037,China)

机构地区：[1]南京林业大学机械电子工程学院,江苏南京210037

出　　处：《传感器与微系统》2020年第8期30-31,35,共3页Transducer and Microsystem Technologies

基　　金：江苏省自然科学基金资助项目(BK20160935);江苏省属高校自然科学基金面上资助项目(16KJB460015);南京林业大学青年创新基金资助项目(CX2016027);南京林业大学大学生创新资助项目(201810298002Z)。

摘　　要：从门电压控制角度,运用COMSOL多物理场耦合方法研究溶液浓度对纳米孔检测生物分子分辨率的调控机理。当纳米孔两端溶液浓度一致时,各个浓度下,门电压为-1 V时,纳米孔分辨率达到最大值δmax,最大分辨率δmax随着浓度的增加而逐渐降低。当纳米孔两端溶液浓度不同时,纳米孔δmax比浓度一致的δmax要大;若Trans(反式)端与Cis(顺式)端溶液浓度的比值小于1时,纳米孔最大分辨率对应的门电压值为1 V;研究表明通过门电压和浓度差调控法可以获得更高的纳米孔分辨率。The COMSOL multi-physical field coupling method is used to study on the regulation mechanism of solution concentration on the biomolecule resolution of nanopore from the perspective of gate voltage control.When the concentration of the solution at both ends of the nanopore are the same,the resolution of the nanopore reaches the max imum valueδmax at the gate voltage of-1 V at each concentration,and the maximum resolutionδmax gradually decreases with the increase of the concentration.When the solution concentration of the two ends of the nanopore is different,the nanoporeδmax is larger than the concentratioδmax;if the ratio of the concentration of the Trans terminal to the Cis solution is less than 1,the maximum resolution of the nanopore corresponds to a gate voltage of 1 V,research shows that higher nanopore resolution can be obtained by gate voltage and concentration regulation method.

关 键 词：纳米孔 分辨率 门电极 浓度差 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] Q503[自动化与计算机技术—控制科学与工程]