克罗恩病组织中网状蛋白-1C的表达水平及意义  

Reticulon-1C expression and significance in Crohn′s disease tissue

作　　者：张磊[1] 张李群[1] 王冬梅 周怡[1] ZHANG Lei;ZHANG Liqun;WANG Dongmei;ZHOU Yi(Department of Gastroenterology,Punan Hospital,Pudong New District,Shanghai 200125,China)

机构地区：[1]上海市浦东新区浦南医院消化内科,200125

出　　处：《国际消化病杂志》2020年第4期252-255,264,共5页International Journal of Digestive Diseases

摘　　要：目的探究克罗恩病(CD)组织中网状蛋白-1C(RTN-1C)的表达水平及意义。方法选择2016年3月至2018年1月确诊并接受治疗的113例CD患者作为研究对象。用蛋白质免疫印迹法检测CD组织中RTN-1C的表达水平,并分析其与内镜下疾病活动度及预后的关系。结果随着CD组织中RTN-1C表达水平的升高,其内镜下疾病活动度降低。CD患者的RTN-1C水平与CD简化内镜评分(SES-CD)呈负相关关系(P<0.05)。113例CD患者中有34例(30.09%)患者的预后不良。预后不良患者的RTN-1C水平低于预后良好患者,差异有统计学意义(P<0.05)。RTN-1C诊断CD患者预后的受试者工作特征曲线(ROC)下面积(AUC)、最佳截断点、敏感度和特异度分别为0.809、1.91、91.18%和58.23%。单因素及Logistic多因素分析结果显示,疾病行为、肛周病变是CD患者预后的独立危险因素(P<0.05),RTN-1C是CD患者预后的独立保护因素(P<0.05)。结论CD组织中RTN-1C表达水平越低提示病情越严重。检测CD患者的RTN-1C表达水平有利于判断预后。Objective This paper intends to explore the expression and significance of reticulon-1C(RTN-1C)in Crohn′s disease(CD)tissues.Methods A total of 113 patients with CD who were diagnosed and treated in Punan Hospital,Pudong New District from March 2016 to January 2018 were selected as study subjects.The expression of RTN-1C in CD tissue was detected by western blotting,and the relationship between RTN-1C expression and endoscopic disease activity and prognosis was analyzed.Results As the expression of RTN-1C in the CD tissue increased,the endoscopic disease activity decreased.There was a negative correlation between the expression of RTN-1C and SES-CD in CD patients(P<0.05).Of the 113 patients with CD,34 cases(30.09%)had a poor prognosis.The expression of RTN-1C in patients with poor prognosis of CD was lower than that in patients with good prognosis,with a statistically significant difference(P<0.05).The area under the ROC curve(AUC),optimal truncation point,sensitivity,and specificity of prognosis in CD patients diagnosed by RTN-1C were 0.809,1.91,91.18%,and 58.23%,respectively.The univariate and Logistic multivariate analysis showed that disease behavior and perianal lesions were independent risk factors for the prognosis of CD patients(P<0.05),and RTN-1C was an independent protective factor for the prognosis of CD patients(P<0.05).Conclusions As the expression of RTN-1C in CD tissue decreases,the severity of the disease increases.Detection of RTN-1C expression in CD patients is helpful in judging its prognosis.

关 键 词：克罗恩病 网状蛋白-1C 内镜下疾病活动度 预后 

分 类 号：R73[医药卫生—肿瘤]