颠茄生物碱代谢过程中关键酶的研究概况  

Research on Key Enzymes in Alkaloid Metabolism of Belladonna

作　　者：刘佳[1] 肖倩 Liu Jia;Xiao Qian(Xi'an Peihua University Medical College,Shaanxi Xi'an 710000)

机构地区：[1]西安培华学院医学院,陕西西安710000

出　　处：《生物化工》2020年第4期123-125,共3页Biological Chemical Engineering

基　　金：西安培华学院校级资助项目(PHKT19071)。

摘　　要：颠茄是一种茄科颠茄属多年生草本植物,全草可入药,是民间传统的药用植物,全株富含托品烷类生物碱,临床主要用于治疗麻痹症、晕动症、胃肠痉挛性绞痛和三叉神经痛等症。但颠茄自然繁殖受限因素多,现存野生种群较少,且野生颠茄中托品烷类生物碱含量很低。本文主要介绍了在颠茄托品烷类生物碱合成途径中关键研究概况,以期为后人利用基因工程技术获取高产托品烷类生物碱提供参考,解决托品烷类生物碱含量低的问题。Belladonna is a kind of perennial herb of Solanaceae and belladonna.The whole plant can be used as medicine.It is a traditional folk medicine plant,and the whole plant is rich in tropine alkaloids.It is mainly used to treat paralysis,motion sickness,gastrointestinal spasm colic and trigeminal neuralgia.However,there are many limited factors in the natural reproduction of belladonna,few existing wild populations,and the content of tropine alkaloids in wild belladonna is very low.This paper mainly introduces the research situation of the key enzyme pmt and its gene in the synthesis pathway of belladonna tropine alkaloids,in order to obtain high-yield tropine alkaloids and solve the problem of low content of tropine alkaloids for future generations by using genetic engineering technology.

关 键 词：颠茄 托品烷类生物碱 氮甲基腐氨转移酶 基因工程 

分 类 号：Q943.2[生物学—植物学]