SARS、MERS和COVID-19感染所致肝损伤的临床特征及机制  

Clinical features and pathogenesis of liver injury caused by SARS,MERS and COVID-19

作　　者：龚航 黄忠[1] 刘先丽 GONG Hang;HUANG Zhong;LIU Xianli(Department of Gastroenterology,The First People’s Hospital of Zigong,Zigong,Sichuan 643000,China;Department of Ultrasound,Zigong Hospital of Traditional Chinese Medicine,Zigong,Sichuan 643000,China)

机构地区：[1]自贡市第一人民医院消化内科,四川自贡643000 [2]自贡市中医医院超声科,四川自贡643000

出　　处：《临床肝胆病杂志》2020年第8期1887-1890,共4页Journal of Clinical Hepatology

摘　　要：2019新型冠状病毒导致的新型冠状病毒疾病已对全球公共卫生安全构成严重威胁。严重病例除了肺部疾病外伴有不同程度的肝损伤。以往研究表明,急性呼吸系统综合征冠状病毒和中东呼吸综合征冠状病毒感染者也可出现常见的肝损伤,且与疾病严重程度密切相关。主要从三大高致病性人类冠状病毒入手,分别阐述相关肝损伤的临床特点和机制,以供临床医生更清楚地认识该类病毒及作出更准确的决策。Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has become a serious threat to global public health security.Besides lung diseases,severe cases are also accompanied by varying degrees of liver injury.Previous studies have shown that patients infected with severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus may also suffer from liver injury,which is closely associated with disease severity.This article elaborates on the clinical features and pathogenesis of liver injury caused by these three types of highly pathogenic human coronavirus,in order to help clinicians better understand this disease and make accurate decisions.

关 键 词：冠状病毒属 肝损伤 肽基二肽酶A 

分 类 号：R575[医药卫生—消化系统]