缺氧微环境与肝病发生发展的关系  

Association of hypoxic microenvironment with the development and progression of liver diseases

作　　者：李志国[1,3] 杨先照[1,3] 李小科[1,3] 马浔[4] 王姗 张梅 叶永安[1,3] LI Zhiguo;YANG Xianzhao;LI Xiaoke;MA Xun;WANG Shan;ZHANG Mei;YE Yongan(Department of Gastroenterology,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Department of Clinical Laboratory,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China;Institute of Liver Diseases,Beijing University of Chinese Medicine,Beijing 100700,China;Beijing Xing Yuan Jin Fang Clinic of Chinese Medicine,Beijing 101300,China)

机构地区：[1]北京中医药大学东直门医院消化科,北京100700 [2]北京中医药大学东直门医院检验科,北京100700 [3]北京中医药大学肝病研究所,北京100700 [4]北京杏园金方国医医院,北京101300

出　　处：《临床肝胆病杂志》2020年第8期1891-1895,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金青年科学基金项目(81603555);北京市自然科学基金青年科学基金项目(7174319)。

摘　　要：缺氧微环境是肝病的一种普遍现象,贯穿于肝病发生发展的始终。近年来对肝纤维化及肝细胞癌组织缺氧微环境的研究也越来越受到重视。缺氧诱导因子是目前发现的最重要的缺氧应激因子。综述了肝脏及肝病的缺氧微环境特点,进一步探讨了缺氧诱导因子的过表达与肝细胞损伤、纤维化形成及肝细胞恶性转化的关系。Hypoxic microenvironment is a common phenomenon of liver diseases and runs through the whole process of the development and progression of liver diseases.In recent years,the research on liver fibrosis and hypoxic microenvironment of hepatocellular carcinoma has attracted more and more attention.Hypoxia-inducible factor(HIF)is the most important hypoxic stress factor found at present.This article reviews the characteristics of hypoxic microenvironment in the liver and liver diseases and further elaborates on the association of HIF overexpression with hepatocyte damage,formation of fibrosis,and malignant transformation of hepatocytes.

关 键 词：肝疾病 缺氧微环境 缺氧诱导因子 

分 类 号：R575[医药卫生—消化系统]