不同年龄段急性脑梗死患者重组组织型纤溶酶原激活剂静脉溶栓的效果分析  

Analysis of thrombolysis effect of recombinant tissue plasminogen activator in different ages of patients with acute cerebral infarction

作　　者：王磊 WANG Lei(Department of Internal Medicine,Xuecheng District Traditional Chinese Medicine Hospital,Zaozhuang 277000,China)

机构地区：[1]薛城区中医院内科,277000

出　　处：《中国实用医药》2020年第19期32-34,共3页China Practical Medicine

摘　　要：目的探究不同年龄段急性脑梗死患者重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓的效果。方法112例急性脑梗死患者,按年龄不同分为知命组(<60岁,35例)、花甲组(60~70岁,41例)、古稀组(71~80岁,36例)。三组均采用rt-PA静脉溶栓治疗,比较三组临床疗效、改良Rankin量表(mRs)评分及3个月内死亡情况。结果知命组患者总有效率91.43%明显高于花甲组的73.17%及古稀组的50.00%,花甲组患者总有效率明显高于古稀组,差异具有统计学意义(P<0.05)。知命组mRs评分0~1分患者占比51.43%明显高于花甲组的26.83%与古稀组的8.33%,花甲组mRs评分0~1分患者占比明显高于古稀组,差异具有统计学意义(P<0.05)。知命组患者死亡率5.71%明显低于花甲组的21.95%与古稀组的44.44%,花甲组患者死亡率明显低于古稀组,差异具有统计学意义(P<0.05)。结论rt-PA对各年龄段患者均有显著效果,其中年龄越低效果越好。Objective To investigate the thrombolysis effect of recombinant tissue plasminogen activator(rt-PA)in different ages of patients with acute cerebral infarction.Methods A total of 112 patients with acute cerebral infarction were divided into Zhiming group(<60 years old,35 cases),Huajia group(60-70 years old,36 cases)and Guxi group(71-80 years old,41 cases)by different ages.Three groups all treated by rt-PA intravenous thrombolysis,and the clinical efficacy,modified Rankin scale(mRs)score and death within 3 months were compared among three groups.Results The total effective rate 91.43%of Zhiming group was obviously higher than that of Huajia group 73.17%and Guxi group 50.00%,and the total effective rate of Huajia group was obviously higher than that of Guxi group.The difference was statistically significant(P<0.05).The proportion of patients with mRs score of 0-1 points in Zhiming group was 51.43%,which was significantly higher than that of 26.83%in Huajia group and 8.33%in Guxi group,and the proportion of patients with mRs score of 0-1 points in Huajia group was significantly higher than that of Guxi group.The difference was statistically significant(P<0.05).The death rate 5.71%of Zhiming group was obviously lower than Huajia group 21.95%and Guxi group 44.44%,and the death rate of Huajia group was obviously lower than that of Guxi group.The difference was statistically sigificant(P<0.05).Conclusion rt-PA has significant effect on patients of all ages,and the lower the age,the better the effect.

关 键 词：重组组织型纤溶酶原激活剂 静脉溶栓 急性脑梗死 不同年龄 

分 类 号：R743.33[医药卫生—神经病学与精神病学]