环状RNA在病毒感染性疾病中的作用机制  

The roles and mechanisms of circular RNAs in viral infectious diseases

作　　者：李池慧 陶然[2] 李伟[2] 尚世强[2] Li Chihui;Tao Ran;Li Wei;Shang Shiqiang(Department of Laboratory Medicine,Jinhua People's Hospital,Jinhua 323000,China;Lab Center,Children's Hospital,Zhejiang University School of Medicine,Hangzhou 310052,China)

机构地区：[1]金华市人民医院检验科,金华323000 [2]浙江大学医学院附属儿童医院实验检验中心国家儿童健康与疾病临床医学研究中心,杭州310052

出　　处：《中华检验医学杂志》2020年第7期758-762,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81971422)。

摘　　要：环状RNA(circRNA)是共价闭合环状单链RNA,具有相对丰富、保守、稳定、特异等特征。研究表明circRNA在基因表达过程中发挥重要调控作用,并在癌症、心血管疾病、神经系统疾病和自身免疫病等发病过程中参与多种信号通路调控。近年有报道circRNA在病毒感染性疾病中表达异常,circRNA有望成为病毒感染性疾病的潜在生物标志物,还可能作为潜在的靶点为疾病治疗提供依据。本文简要介绍了circRNA与病毒感染性疾病的研究进展,包括circRNA的差异性表达及其转录调控翻译的机制等,为今后的研究提供参考。Circular RNAs(circRNAs)are covalently linked circular single-stranded RNAs,which have the characteristics like abundance,conservation,stabilization and specificity.It is demonstrated that circRNA plays an important roles in the regulation of gene expression and multiple signal pathways of diseases such as cancer,cardiovascular disease,nervous system disease and autoimmune disease.In recent years,it has been reported that circRNAs are expressed abnormally in viral infectious diseases.CircRNA is expected to be a potential biomarker for viral infectious diseases and a potential target for disease therapy.In this review we briefly introduced the research progression of the roles and mechanisms of circular RNAs in viral infectious diseases and provides the references for future study.

关 键 词：病毒性疾病 RNA 环状 生物标记 

分 类 号：R363[医药卫生—病理学]