中国北方城市体检健康居民营养状况及微炎症状态的调查  

Nutritional and microinflammatory status of healthy residents in cities of Northern China

作　　者：林淑芃[1] 孟金铃 孙晓伟 刘秀娟[1] 孙雪峰[1] Lin Shupeng;Meng Jinling;Sun Xiaowei;Liu Xiujuan;Sun Xuefeng(Department of Nephrology,Chinese PLA General Hospital,Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Diseases,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心肾脏病科,解放军肾脏病研究所,肾脏疾病国家重点实验室,国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室,北京100853

出　　处：《中华医学杂志》2020年第28期2216-2221,共6页National Medical Journal of China

基　　金：国家重点基础研究发展计划(973计划)(2013CB530800);国家重点研发计划项目(2016YFC0906202)。

摘　　要：目的调查中国北方城市体检健康居民膳食摄入、营养和微炎症状况,探讨营养状况随年龄变化情况及其相关因素。方法2014年1至12月在中国北方3座城市(北京、大连、沈阳)采取随机整群抽样的方法,对30岁及以上体检基本健康的居民进行膳食营养素摄入调查,空腹抽血测定血清学营养指标和微炎症指标。结果符合入选标准903人,年龄30~95(58±15)岁,其中男420人(46.5%)。膳食调查结果显示,各年龄组居民钠和脂肪的平均摄入量均高于中国居民营养素摄入推荐量(DRIs),而钙和维生素A的每日平均摄入量均未达DRIs,并且随年龄增加,摄入量逐渐减少。其他营养素平均摄入量达标。调查人群的营养血清学指标均在正常参考范围之内,血清转铁蛋白、白蛋白与年龄呈负相关(r=-0.321、-0.236,均P<0.001),空腹血糖、血清胆固醇、低密度脂蛋白、高密度脂蛋白与年龄呈正相关(r=0.289、0.477、0.396、0.351,均P<0.001)。调查人群的微炎症指标白细胞介素6(IL-6)和超敏C反应蛋白在正常参考范围之内,与年龄均呈正相关(r=0.386,0.444,均P<0.001)。将各项营养指标分别与营养素摄入、年龄和炎症指标进行多重线性回归分析,结果显示,血清转铁蛋白、前白蛋白、白蛋白、空腹血糖、血清胆固醇、低密度脂蛋白、高密度脂蛋白只与年龄独立相关(均P<0.001)。结论中国北方城市抽样健康居民的营养素摄入量基本达到DRIs推荐量,血清学营养指标和微炎症指标在正常范围之内,但呈随年龄变化趋势,而微炎症状态与血清学营养指标无明显相关性。Objective To investigate the status of dietary intake,nutrition and micro-inflammation among healthy residents in cities of Northern China,and explore the changes of nutritional status with age and its influencing factors.Methods From January to December 2014,a survey on dietary nutrient intake was conducted among residents≥30 years old who were examined as basically healthy in three randomly selected cities of Northern China(Beijing,Dalian,Shenyang).Serum nutritional and microinflammatory indicators were measured by fasting blood sampling.Results A total of 903 individuals met the eligibility criteria,and 420 individuals were male(46.5%).The age ranged from 30 to 95(58±15)years old.Dietary survey results showed that the dietary intakes of sodium and fat in all age groups were significantly higher than the adequate intake(AI)values recommended by dietary reference intakes(DRIs)of Chinese residents in 2013,while the daily intakes of calcium and vitamin A in all age groups did not reach AI values and gradually decreased with increasing age.Other nutrients basically reached the recommended intake of DRIs.The nutritional serological indexes of the sampled population were within the normal range,but the levels of transferrin and albumin decreased with age(r=-0.321 and-0.236,both P<0.001).Fasting blood glucose,serum cholesterol,low-density lipoprotein(LDL)and high-density lipoprotein(HDL)increased with age(r=0.289,0.477,0.396 and 0.351,all P<0.001).The values of interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)were within the normal range and positively correlated with age(r=0.386,0.444,both P<0.001).The results of regression analysis revealed that serum transferrin,prealbumin,albumin,fasting blood glucose,serum cholesterol,LDL and HDL were only related to age independently(all P<0.001).Conclusions The nutrient intakes of the healthy residents in cities of Northern China basically reached the recommended nutrient intakes,and the serological nutritional index and micro-inflammatory index of the healt

关 键 词：膳食调查 营养状况 炎症 衰老 

分 类 号：R194.3[医药卫生—卫生事业管理]