口腔健康状况与食管鳞癌发病风险的研究进展  

Research progress on oral health status and risk of esophageal squamous cell carcinoma

作　　者：张鑫[1] 刘其伟 焦叶林 朱亚飞[1] 高社干[1] 齐义军 Zhang Xin;Liu Qiwei;Jiao Yelin;Zhu Yafei;Gao Shegan;Qi Yijun(Henan Key Laboratory of Cancer Epigenetics,Cancer Institute,the First Affiliated Hospital,College of Clinical Medicine of Henan University of Science and Technology,Henan Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,河南科技大学肿瘤研究所肿瘤医院,河南省肿瘤表观遗传重点实验室,河南洛阳471003

出　　处：《现代肿瘤医学》2020年第17期3070-3074,共5页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:U1604191,81872037)。

摘　　要：食管癌(esophageal cancer,EC)是世界上最常见的恶性肿瘤之一,进展迅速及预后不良。食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)约占EC的90%以上,存在明显的地域、性别及年龄等差异。目前大量研究显示口腔卫生不良是ESCC发病的危险因素之一,但是口腔卫生不良与多种因素相关,且混杂因素较多,因此本综述从牙齿缺失、牙周炎及口腔微生态三方面总结这些因素与ESCC之间的关系,为ESCC高危人群筛查、预防提供新靶标。Esophageal cancer(EC)is one of the most common malignant diseases in the world with rapid progress and poor prognosis.Esophageal squamous cell carcinoma(ESCC),which exhibits obvious differences in regional distribution,gender and age,accounts for more than 90%of EC.A large number of studies have shown that poor oral health is one of the risk factors for ESCC.Because poor oral health is related to multiple etiological factors and there are many confounding factors implicated.This review elaborates the relationships between these factors with ESCC from three aspects including tooth loss,periodontal diseases and oral microbiota,and aimed to provide new targets for surveillance and prevention of ESCC high-risk populations.

关 键 词：食管鳞状细胞癌 牙齿缺失 牙周疾病 口腔卫生不良 口腔微生态 

分 类 号：R735.1[医药卫生—肿瘤]