中西医结合治疗肝胃不和型功能性消化不良临床研究  

Clinical study on the treatment of functional dyspepsia of liver-stomach disharmony with integrated traditional Chinese and western medicine

作　　者：周世龙 濮孝娟 Zhou Shilong;Pu Xiaojuan(Department of Spleen and Stomach Diseases,Wenling Hospital of Traditional Chinese Medicine,Wenling,Zhejiang 317599,China;Department of Gastroenterology,the Traditional Chinese Medicine Hospital of Zhejiang Province,Hangzhou,Zhejiang 310006,China)

机构地区：[1]温岭市中医院脾胃病科,浙江省317599 [2]浙江省中医院消化科,杭州310006

出　　处：《中国基层医药》2020年第16期1938-1942,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨中西医结合治疗肝胃不和型功能性消化不良的临床疗效。方法选择温岭市中医院2018年6月至2019年6月收治的功能性消化不良患者92例,依据随机数字表法分为观察组46例与对照组46例。对照组口服马来酸曲美布汀治疗,观察组在对照组基础上结合自拟中药汤剂治疗。两组疗程均为4周。比较两组治疗疗效,治疗前后中医症候积分和胃动力学指标变化,及不良反应发生情况。结果观察组总有效率(93.48%)高于对照组(69.57%)(χ^2=8.731,P<0.05)。两组治疗后上腹痛、腹胀、早饱和嗳气反酸积分均较治疗前降低(均P<0.05);观察组治疗后上腹痛、腹胀、早饱和嗳气反酸积分均低于对照组(t=11.068、22.320、15.073、14.369,均P<0.05)。两组治疗后血清胃动素(MLT)和瘦素(LEP)水平较治疗前升高,而促肾上腺皮质激素释放激素(CRH)水平较治疗前降低,差异均有统计学意义(均P<0.05);观察组治疗后血清MLT和LEP水平均高于对照组,而CRH水平低于对照组,差异均有统计学意义(t=12.022、15.884、16.536,均P<0.05)。观察组不良反应发生率(4.35%)低于对照组(23.91%)(χ^2=7.256,P<0.05)。结论中西医结合治疗肝胃不和型功能性消化不良患者疗效良好,可改善胃动力,且不良反应少,值得临床借鉴。Objective To explore the clinical effect of integrated traditional Chinese and western medicine in the treatment of functional dyspepsia of liver-stomach disharmony.Methods From June 2018 to June 2019,92 patients with functional dyspepsia admitted to Wenling Hospital of Traditional Chinese Medicine were divided into observation group(46 cases)and control group(46 cases)according to random number table method.The control group was treated with trimebutine maleate orally,while the observation group was treated with self-made traditional Chinese medicine decoction on the basis of the control group.Both two groups were treated for 4 weeks.The therapeutic effect,the changes of TCM symptom score,gastric motility index and adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group(93.48%)was higher than that of the control group(69.57%)(χ^2=8.731,P<0.05).After treatment,the scores of upper abdominal pain,abdominal distension and early saturated belch acid in the two groups were lower compared with those before treatment(all P<0.05).After treatment,the scores of upper abdominal pain,abdominal distension and early saturated belch acid in the observation group were lower than those in the control group(t=11.068,22.320,15.073,14.369,all P<0.05).After treatment,the levels of serum MLT and LEP in the two groups were higher than those before treatment(all P<0.05),while the level of CRH were lower than those before treatment(all P<0.05).After treatment,the levels of serum MLT and LEP in the observation group were higher than those in the control group,while the level of CRH in the observation group was lower than that in the control group,the differences between the two groups were statistically significant(t=12.022,15.884,16.536,all P<0.05).The incidence of adverse reactions in the observation group(4.35%)was lower than that in the control group(23.91%)(χ^2=7.256,P<0.05).Conclusion The combination of traditional Chinese and western medicine has

关 键 词：马来酸曲美布汀 自拟中药汤剂 肝胃不和型 功能性消化不良 疗效 中医症候 胃动力学 不良反应 

分 类 号：R57[医药卫生—消化系统]