治脾法联合活血化瘀法对消化道肿瘤患者血清免疫球蛋白的影响  

Effects of TCM therapy principles of strengthening the spleen combined with activating blood circulation and removing blood stasis on serum immunoglobulins in patients with gastrointestinal tumors

作　　者：王勇军 施媛 阮广欣[2] WANG Yong-jun;SHI Yuan;RUAN Guang-xin(Department of Spleen and Stomach,Yangpu District Hospital of Traditional Chinese Medicine,Shanghai 200091,China;Department of Oncology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200000,China)

机构地区：[1]上海市杨浦区中医医院脾胃病科,上海200091 [2]上海中医药大学附属龙华医院肿瘤科,上海200000

出　　处：《中国肿瘤临床与康复》2020年第7期832-835,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨治脾法联合活血化瘀法对消化道肿瘤患者血清免疫球蛋白的影响。方法选取2019年2月至2020年3月间上海市杨浦区中医医院和上海中医药大学附属龙华医院收治的128例消化道肿瘤患者,采用随机数字表法分为研究组和对照组,每组64例。对照组患者采用治脾法治疗,研究组患者采用治脾法联合活血化瘀法治疗,比较两组患者治疗后T细胞亚群、血小板计数情况、血清免疫球蛋白G(IgG)、IgA、IgM指标变化情况及卡式功能评分(KPS)。结果治疗后,研究组患者CD4+和CD4+/CD8+指标均高于对照组,CD8+指标低于对照组,差异均有统计学意义(均P <0. 05)。治疗后第1周、第2周和第4周,研究组患者血小板计数均高于对照组,差异均有统计学意义(均P <0. 05)。治疗后,研究组患者IgA指标高于对照组,IgG和IgM指标均低于对照组,差异均有统计学意义(均P <0. 05)。治疗后第1周、第2周和第4周,研究组患者KPS评分均高于对照组,差异均有统计学意义(均P <0. 05)。结论消化道肿瘤采用治脾法联合活血化瘀法治疗,可改善患者外周血小板计数和T细胞亚群,效果较好,可在临床进一步推广使用。Objective To investigate the effects of TCM therapy principles of strengthening the spleen combined with activating blood circulation and removing blood stasis on serum immunoglobulins levels in patients with gastrointestinal tumors. Methods A total of 128 patients with gastrointestinal cancer who were admitted to Yangpu District Hospital of Traditional Chinese Medicine and Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were selected from February 2019 to March 2020.Random number table method was used to assign the patients to a study group and a control group with 64 patients each. The study group received therapy based on TCM therapy principles of strengthening the spleen combined with activating blood circulation and removing blood stasis. The control group only received therapy based on TCM therapy principles of strengthening the spleen. Changes in T cell subsets,platelet count,serum immunoglobulin G( IgG),IgA,IgM indicators and Karnofsky performance scale( KPS) score were compared between the two groups before and after the treatment. Results The levels of CD4+and CD4+/CD8+were higher in the study group than in the control group( all P < 0. 05),while the level of CD8+were lower in the study group than in the control group( P < 0. 05). The platelet count was higher in the study group than that in the control group at 1 week,2 weeks and 4 weeks after the treatment( all P <0. 05). After the treatment,IgA levels were higher in the study group than in the control group,while IgG and IgM levels were lower in the study group than in the control group( all P < 0. 05). KPS scores were higher in the study group than in the control group at 1 week,2 weeks and 4 weeks after the treatment( all P < 0. 05). Conclusion TCM therapy principles of strengthening the spleen combined with activating blood circulation and removing blood stasis can significantly improve the peripheral platelet count and T cell subgroup with significant efficacy in the treatment of gastrointestinal cancer. It is w

关 键 词：治脾法 活血化瘀法 消化道肿瘤 IgG IGA IGM 

分 类 号：R735[医药卫生—肿瘤]