Role of semi-purified andrographolide from Andrographis paniculata extract as nano-phytovesicular carrier for enhancing oral absorption and hypoglycemic activity  

作　　者：Vinod Kumar Verma Md.Kamaruz Zaman Shekhar Verma Santosh Kumar Verma Khomendra Kumar Sarwa 

机构地区：[1]Department of Pharmaceutical Sciences,Dibrugarh University,Dibrugarh 786004,India [2]State Food and Drug Testing Laboratory,Raipur 492001,India [3]University College of Pharmacy,Pt.Deendayal Upadhyay Health,Science and Aayush University,Raipur-492001,Chhattisgarh,India [4]School of Chemistry and Chemical Engineering,Yulin University,Yulin 719000,China [5]Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization,Yulin University,Yulin 719000,China [6]Department of Pharmacy Government Girl’s Polytechnic,Raipur 492001,India

出　　处：《Chinese Herbal Medicines》2020年第2期142-155,共14页中草药（英文版）

基　　金：financial support through UGC-JRF in Engineering and Technology(Vide-F No.10-01/2008 SA-I)。

摘　　要：Objective:Andrographis paniculata is a well-known medicinal plant in Southeast Asia,India and China.The plant contains andrographolide(AN),a very important phytochemical used in various health problems.However,AN is low in oral absorption bioavailability of AN due to the rapid clearance and high protein binding capacity.Methods:The present study was aimed to develop a nano-phytovesicular formulation of semi-purified AN extracts from a naturally occurring phospholipid(soya phosphatidylcholine)in order to increase the oral absorption and antihyperglycemic activity in rats.Results:The nano-phyto vesicle of semi-purified AN extracts equivalent to 25 mg/kg AN significantly protected the hyperglycemic condition of rats.The in vitro and in vivo experiments results proved that the nano-phytovesicular system of plant extracts containing AN produced better oral absorption,bioavailability and improved antihyperglycemic activity compared with that of free AN at dose of 50 mg/kg.Conclusion:Hence,the prepared semi-purified extract nano-phytovesicular system is helpful in solving the problem of rapid clearance of AN.

关 键 词：Andrographis paniculata(Burm.f.)Nees ANDROGRAPHOLIDE hypoglycemic activity liquid dispersion nano-phyto vesicle soya phosphatidylcholine 

分 类 号：R283.6[医药卫生—中药学]