血清S-CD105 VEGF MMP9表达与非小细胞肺癌根治术后再复发的关系  

The Association Between the Expressions of Serum S-CD105 VEGF MMP9 and Recurrence of Non-small Cell Lung Cancer After Radical Operation

作　　者：李彦明[1] 郝雁冰[1] 杨继雷[1] 李传贵[1] 陈万生[1] LI Yanming;HAO Yanbing;YANG Jilei(The First Affiliated Hospital of Hebei North University, Hebei Zhangjiakou 075061, China)

机构地区：[1]河北北方学院附属第一医院,河北张家口075061

出　　处：《河北医学》2020年第8期1281-1286,共6页Hebei Medicine

基　　金：河北省张家口市科技计划自筹经费项目,(编号:1921048D)。

摘　　要：目的:探讨血清可溶性CD105(S-CD105)、血管内皮生长因子(VEGF)、基质金属蛋白酶9(MMP9)表达与非小细胞肺癌(NSCLC)根治术后再复发的关系。方法:选取2014年9月至2017年10月本院收治的102例行NSCLC根治术患者作为研究对象,术后随访2年,根据患者复发情况分为复发组(n=44)和未复发组(n=52),选取同期60例体检健康者作为对照组,采用酶联免疫吸附法(ELISA)检测血清S-CD105、VEGF、MMP9水平,观察三组受试者血清S-CD105、VEGF、MMP9水平变化,S-CD105、VEGF、MMP9S-CD105、VEGF、MMP9不同水平患者复发率,三者表达对NSCLC术后复发的预测价值及影响因素分析。结果:复发组患者血清S-CD105、VEGF、MMP9水平明显高于未复发组、对照组(P<0.05);血清S-CD105、VEGF、MMP9高表达组患者复发率均高于低表达组(P<0.05);MMP9预测NSCLC术后复发的特异性最高,但敏感性较低;VEGF预测的AUC最高,敏感度、特异性略高于S-CD105的敏感度、特异性;TNM分期、化疗周期、S-CD105、VEGF、MMP9是影响NSCLC术后复发的独立危险因素。结论:NSCLC术后复发患者血清S-CD105、VEGF、MMP9高表达,三者高表达患者术后复发率高,三者对患者术后复发有一定预测价值,是术后复发的独立危险因素。Objective:To investigate the relationship between the expression of serum soluble CD105(S-CD105),vascular endothelial growth factor(VEGF),matrix metalloproteinase 9(MMP9)and recurrence of non-small cell lung cancer(NSCLC)after radical operation.Methods:102 patients with NSCLC treated in our hospital from September 2014 to October 2017 were selected as the study subjects,who were followed up for 2 years.They were divided into recurrence group(n=44)and non-recurrence group(n=52)based on the recurrence.Another 60 healthy persons were selected as the control group during the same period.The levels of serum S-CD105,VEGF and MMP9 were detected by ELISA,the changes of levels of serum S-CD105,VEGF and MMP9 were observed,the recurrence rates of patients with different levels of S-CD105,VEGF,MMP9S-CD105,VEGF and MMP9 were observed,and the predictive value of the expression of three factors for recurrence after NSCLC and the influencing factors were analyzed.Results:The levels of serum S-CD105,VEGF and MMP9 in the relapsed group were significantly higher than those in the non-relapsed group and the control group(P<0.05).The recurrence rate of patients with high expressions of serum S-CD105,VEGF and MMP9 was higher than that of patients with low expressions(P<0.05).MMP9 had the highest specificity but lower sensitivity in predicting recurrence of NSCLC,and AUC predicted by VEGF was the highest,and the sensitivity and specificity were slightly higher than those predicted by S-CD105.TNM stage,chemotherapy cycle,S-CD105,VEGF and MMP9 were independent risk factors for recurrence of NSCLC.Conclusion:Serum S-CD105,VEGF and MMP9 are highly expressed in patients with recurrent NSCLC,postoperative recurrence rate of patients with high expressions of the three factors is high.These three factors have certain predictive values for postoperative recurrence and are independent risk factors for postoperative recurrence.

关 键 词：非小细胞肺癌 根治术 复发 可溶性CD105 血管内皮生长因子 基质金属蛋白酶9 

分 类 号：R73[医药卫生—肿瘤]