超声造影联合定量分析技术在甲状腺良恶性结节诊断中的应用分析  

Contrast-Enhanced Ultrasound Combined with Quantitative Analysis in the Diagnosis of Benign and Malignant Thyroid Nodules

作　　者：塔娜[1] 王霞[1] 景江新[1] TA Na;WANG Xia;JING Jiangxin(The Second Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830063, China)

机构地区：[1]新疆医科大学第二附属医院超声科,新疆乌鲁木齐830063

出　　处：《河北医学》2020年第8期1343-1347,共5页Hebei Medicine

基　　金：新疆维吾尔自治区2019年自然科学基金项目,(编号:2019D01C241)。

摘　　要：目的:探讨超声造影联合定量分析技术在甲状腺良恶性结节诊断中的应用。方法:对2019年5月至2019年12月于我院进行超声造影检查的72例甲状腺结节患者的临床资料进行回顾性分析,观察甲状腺良恶性结节的超声造影增强模式特征,采用时间-强度曲线分析造影剂通过时间(MTT)、峰值强度(Peak)、达到峰值时间(TIP)及曲线下面积(AUC)等血流灌注参数,以术后病理结果作为对照,分析超声造影联合定量分析技术的诊断价值。结果:超声造影显示,72例甲状腺结节患者中,良性结节43个,恶性结节29个。良性结节的病理类型为甲状腺腺瘤和结节性甲状腺肿,其超声造影特征为内部均匀增强或无增强,周边环状增强,边界清晰;恶性结节病理类型均为甲状腺乳头状癌,其超声造影特征为低增强或不均匀增强,形态不规则,边界模糊等。经术后病理证实,良性结节47个,恶性结节25个。超声造影检查诊断甲状腺恶性结节的敏感度为88.00%,特异度为85.11%,准确率为86.21%。与甲状腺良性结节相比,甲状腺恶性结节的Peak及AUC较低,TIP较晚(P<0.05)。与甲状腺恶性结节周围正常组织相比,甲状腺恶性结节的Peak及AUC较低,TIP较晚(P<0.05)。与甲状腺良性结节周围正常组织比较,甲状腺良性结节的Peak及AUC略低,TIP略,MTT略慢,但均无显著差异(P>0.05)。结论:超声造影联合定量分析技术可用于甲状腺良恶性结节的鉴别诊断,定量参数Peak、AUC及TIP可反应甲状腺恶性结节的血管灌注规律。Objective:To analyze the application of contrast-enhanced ultrasound combined with quantitative analysis in the diagnosis of benign and malignant thyroid nodules.Methods:Retrospective analysis was conducted of clinical data of 72 patients with thyroid nodules who underwent contrast-enhanced ultrasound examination in our hospital from May 2019 to December 2019.The characteristics of contrast-enhanced ultrasound enhancement mode of benign and malignant thyroid nodules were observed.The time-intensity curve was used to analyze blood flow perfusion parameters such as contrast medium transit time,peak intensity,peak time,and area under the curve.Using the postoperative pathological results as a control,the diagnostic value of contrast-enhanced ultrasound combined with quantitative analysis technology was analyzed.Results:Contrast-enhanced ultrasound showed that among 72 patients with thyroid nodules,43 were benign nodules and 29 were malignant nodules.The pathological types of benign nodules are thyroid adenomas and nodular goiters.Their contrast-enhanced ultrasound features are uniform enhancement or no enhancement inside,peripheral ring enhancement,and clear boundaries.The pathological types of malignant nodules are papillary thyroid carcinoma.Contrast-enhanced ultrasound is characterized by low or uneven enhancement,irregular morphology,and blurred borders.Postoperative pathology confirmed 47 benign nodules and 25 malignant nodules.The sensitivity of contrast-enhanced ultrasound in diagnosing malignant thyroid nodules was 88.00%,the specificity was 85.11%,and the accuracy was 86.21%.Compared with benign thyroid nodules,Peak and AUC in diagnosing malignant thyroid nodules were relatively lower,and had a later TIP(P<0.05).Compared with normal tissues surrounding thyroid malignant nodules,Peak and AUC of thyroid malignant nodules were lower and TIP was later(P<0.05).Compared with normal tissue around benign thyroid nodules,Peak and AUC of benign thyroid nodules were slightly lower,TIP was slightly later,and MTT was sl

关 键 词：超声造影 时间-强度曲线分析 甲状腺结节 

分 类 号：R73[医药卫生—肿瘤]