长链非编码RNA在肿瘤干细胞放射耐受性中的作用  

The role of long non-coding RNAs in radiation tolerance of cancer stem cells

作　　者：姚志峰[1] 姚建新 Yao Zhifeng;Yao Jianxin(Department of Radiotherapy,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;Faculty of Medical Technology,Nanjing Vocational Health College,Nanjing 210038,China)

机构地区：[1]南京医科大学第二附属医院放射治疗科,210011 [2]南京卫生高等职业技术学校医学技术系,210038

出　　处：《中华放射肿瘤学杂志》2020年第8期699-703,共5页Chinese Journal of Radiation Oncology

摘　　要：肿瘤干细胞(CSCs)指肿瘤内部一类具有自我更新能力和多向分化潜能的细胞,虽然仅占整个肿瘤细胞的小部分,却是导致肿瘤发生、扩散和复发的"起源细胞",这也正是肿瘤放疗失败的根源所在。CSCs对放疗具有耐受性,并以直接或间接方式促进肿瘤转移,因而被认为是肿瘤转移的基础。此外,CSCs的异质性可能是造成器官特异性转移的原因之一。长链非编码RNA(lncRNA)是一类长度>200个核苷酸,且无蛋白质编码能力的RNA分子,参与肿瘤发生和发展,并与肿瘤放射耐受性的形成密切相关。近年来肿瘤放射耐受性相关的lncRNA及其与CSCs关系的研究日益成为热点。本文就放疗后lncRNA介导的CSCs的调节以及lncRNA在肿瘤放射耐受中的作用进行综述。Cancer stem cells(CSCs)refer to a kind of cells with self-renewal ability and multi-directional differentiation potential inside the tumor.Although only occupying a small part of the whole cancer cells,they are the"original cells"that cause tumorigenesis,spread and recurrence,which is also the root cause of radiotherapy failure.CSCs are virtually resistant to radiotherapy and promote tumor metastasis either in a direct or indirect manner,which are therefore believed to serve as the basis of tumor metastasis.Moreover,the heterogeneity of CSCs may be responsible for the complexity of organ-specific metastasis.Long non-coding RNAs(lncRNAs)are a class of RNA molecules with over 200 nucleotides in length without protein coding potential,which are involved in the initiation and progression of several cancer types and closely related to the radiation tolerance.Recently,lncRNAs related to tumor radiation tolerance and its relationship with CSCs have attracted widespread attention.In this review,lncRNA-mediated regulation of CSCs following radiotherapy and the role of lncRNA in radiation tolerance were summarized.

关 键 词：长链非编码RNA 肿瘤干细胞 放射耐受性 

分 类 号：R730.55[医药卫生—肿瘤]