The effects of nutritional ketosis induced by Bigu-herbs regimen and ketogenic diet on diseases and aging  

作　　者：Yi-Dan Lu Xiao-Gu Liu Song Zheng 

机构地区：[1]The Fourth Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China [2]The Basic Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China [3]Department of Medical Oncology,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China [4]Department of Medical Oncology,Hangzhou Cancer Hospital,Hangzhou 310006,China [5]Department of Medical Oncology,Affiliated Hangzhou First Hospital,Zhejiang Chinese Medical University,Hangzhou 310006,China

出　　处：《Traditional Medicine Research》2020年第5期322-336,共15页TMR传统医学研究

基　　金：the National Natural Science Foundation of China(81372660);Key Medical Science Research Fund of Hangzhou(2011ZD001);Medical Science Research Fund of Zhejiang Province,China(2013KYA157);Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(2013ZA104);Zhejiang Province Public Welfare Technology Application Research Project(2016C03SA100727);Hangzhou Science and Technology Bureau(20140633B30);Department of Oncology,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine(Hangzhou Cancer Hospital),Hangzhou,Zhejiang 310006,China.

摘　　要：The Bigu-herbs regimen,a Taoism(Taoism is an ancient Chinese Taoist philosophy system)special health-preserving technique to achieve longevity through strict abstinence from food,limits the intake of grains and uses herbs to replace normal diet to gain energy.Practicing Bigu-herbs regimen for several weeks to several years can make one lose weight,prevent diseases,and prolong life.The modern ketogenic diet(KD)mainly limits carbohydrate intake and increase fat intake.The low-carbohydrate,high-fat,and adequate protein diet is well known for its antiepileptic and neurotrophic effects.Limiting the intake of carbohydrate results in energy metabolism reprogramming to mobilize the steatolysis,energize and promote ketone bodies(KBs)production,achieving a state of nutritional ketosis(NK).The researchers summarized how ketone bodies or NK affects diseases and the aging process,as well as the side effects of KD.NK has a favorable effect on caloric intake,lipid parameters,glycemic index,and insulin sensitivity;moreover,it can be used as a treatment option for diabetes,obesity,and other metabolic disorders.NK is recognized as being neuroprotective and is good for epilepsy,Alzheimer’s disease,and emotional disturbance.Targeting the metabolic differences between tumor and normal cells,NK limits the use of glucose and impairs energy metabolism in cancer cells,inhibiting their growth and rendering them susceptible to clinical treatments.NK also affects inflammation and the release of cytokines,regulate gut flora,extend longevity and health span,and preserve physiologic functions.The side effects of KDs are controllable under the guidance of a specially trained dietitian and medical team.

关 键 词：Grain avoidance Bigu-herbs regimen Ketogenic diet Nutritional ketosis Ketone body 

分 类 号：R73[医药卫生—肿瘤]