Cryo-EM structure of human bile salts exporter ABCB11  

作　　者：Liang Wang Wen-Tao Hou Li Chen Yong-Liang Jiang Da Xu Linfeng Sun Cong-Zhao Zhou&Yuxing Chen 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences,University of Science and Technology of China,Hefei,Anhui,China [2]CAS Centre for Excellence in Molecular Cell Science,University of Science and Technology of China,230027,Hefei,Anhui,China

出　　处：《Cell Research》2020年第7期623-625,共3页细胞研究（英文版）

基　　金：This work is supported by the Ministry of Science and Technology of China(2019YFA0508500);the National Natural Science Foundation of China(Grant No.31621002);the Fundamental Research Funds for the Central Universities(YD2070002005).

摘　　要：Dear Editor,Bile is a complex aqueous secretion produced by the liver that facilitates the digestion of lipids in the small intestine.A group of ATP binding cassette(ABC)transporters localizing at the apical canalicular domain of hepatocytes are responsible for the secretion of the bile organic solutes to the bile canaliculi,1 including organic anions,cholesterol,bile salts,glutathione,organic cations and phospholipid(Fig.1a).To date,the 3-D structures of ABCG2,ABCG5/G8,ABCB1,ABCB4 have been reported,2'3 leaving the structures of ABCB11 and ABCC2 unknown,despite we can get some information from the homologous structures of ABCC1,4 ABCB1 and ABCB4.

关 键 词：SALTS STRUCTURE HOMOLOGOUS 

分 类 号：Q486[生物学—生理学]