MMPs基因家族在肺腺癌中的表达及临床意义  

Expressions of MMPs family members and their clinical significances in lung adenocarcinoma*

作　　者：李珂[1] 王娴[1] 王小琦 LI Ke;WANG Xian;WANG Xiaoqi(Department of Clinical Medical Laboratory,Chengdu Third People′s Hospital,Chengdu,Sichuan 610031,China)

机构地区：[1]成都市第三人民医院临床医学检验部,四川成都610031

出　　处：《现代医药卫生》2020年第16期2512-2517,共6页Journal of Modern Medicine & Health

基　　金：四川省成都市科技局基金项目(2018-YF05-00669-SN)。

摘　　要：目的研究基质金属蛋白酶(MMPs)基因家族在肺腺癌中的表达及临床意义。方法检索Oncomine,GEPIA及cBioPortal数据库中有关肺腺癌MMPs(MMP-1/9/11/12/14)的数据集,对数据集进行挖掘并结合文献资料进行荟萃分析。结果Oncomine数据库收集9项研究,943例样本;GEPIA数据库收集830例样本。综合分析发现,肺腺癌组织中MMPs的表达显著高于正常肺组织,差异有统计学意义(P<0.05)。Kaplan-Meier Plotter生存分析表明,MMPs高表达的肺腺癌患者总体病死率高,预后较差,差异有统计学意义(P<0.05)。cBioPortal数据库显示,MMPs在肺腺癌中的突变发生率达39%,且互为正相关。结论MMPs在肺腺癌组织中呈高表达,并与肺腺癌的预后密切相关,有望成为肺腺癌治疗的重要靶点。Objective To study the expression and clinical significance of MMPs gene family in lung adenocarcinoma.Methods The data sets related to lung adenocarcinoma MMPs(MMP-1/9/11/12/14)in the Oncomine,GEPIA and cBioPortal databases were searched.The data sets and conduct meta-analysis combined with literature data were mined.Results The Oncomine database collected 9 studies with 943 samples.The GEPIA database collected 830 samples.Comprehensive analysis found that the expression of MMPs in lung adenocarcinoma tissue was significantly higher than that in normal lung tissue,and the difference was statistically significant(P<0.05).Kaplan-Meier Plotter survival analysis showed that patients with lung adenocarcinoma with high expression of MMPs had a high overall mortality rate and poor prognosis,and the difference was statistically significant(P<0.05).The cBioPortal database showed that the mutation rate of MMPs in lung adenocarcinoma was 39%,and they were positively correlated with each other.Conclusion MMPs are highly expressed in lung adenocarcinoma tissues,and are closely related to the prognosis of lung adenocarcinoma,and are expected to become an important target for the treatment of lung adenocarcinoma.

关 键 词：肺腺癌 MMPs基因 Oncomine数据库 GEPIA数据库 cBioPortal数据库 Kaplan-Meier Plotter数据库 

分 类 号：R73[医药卫生—肿瘤]