神经血管单元功能障碍在创伤性颅脑损伤后神经变性中的作用机制  

Role of neurovascular unit dysfunction in traumatic brain injury-induced neurodegeneration

作　　者：吕雯奇 李仕鹏 周贤喆 巫扬标 姚杰然 陈祥荣[1] Lyu Wenqi;Li Shipeng;Zhou Xianzhe;Wu Yangbiao;Yao Jieran;Chen Xiangrong(Department of Neurosurgery,Second Clinical Medical College,Fujian Medical University,Quanzhou 362000,China)

机构地区：[1]福建医科大学第二临床医学院神经外科,泉州362000

出　　处：《中华神经医学杂志》2020年第8期844-848,共5页Chinese Journal of Neuromedicine

基　　金：福建省自然科学基金(2019J01168);福建省科技创新联合资金项目(2017Y9084)。

摘　　要：创伤性颅脑损伤(TBI)后的病理过程在急性期过后很长的一段时间内仍在继续演变,常出现神经变性和神经退行性后遗症。神经血管单元(NVU)功能障碍导致的微循环血管功能障碍和血脑屏障功能障碍.与众多神经退行性疾病的病理过程密切相关。针对NVU功能障碍病理机制的研究是TBI相关性神经变性的热点研究领域。本文围绕上述内容进行综述。以期为治疗TBI后神经变性提供新的思路。The pathological process continues to evolve for a long time after acute phase of traumatic brain injury(TBD),often coupling with neurodegeneration and neurodegenerative complications.Microvascular dysfunction and blood-brain barrier(BBB)dysfunction caused by neurovascular unit(NVU)dysfunction are closely related to the pathological process of many neurodegenerative diseases.The study on the pathological mechanism of neurovascular unit dysfunction is a promising research field of TBI-related neurodegeneration,and also provides a new idea for the treatment of neurodegeneration after TBI.Therefore,this article mainly reviews these.

关 键 词：颅脑损伤 神经血管单元 血脑屏障 微循环血管 神经变性 

分 类 号：R651.15[医药卫生—外科学]