丁苯酞软胶囊治疗帕金森病认知功能障碍的系统评价  

Systematic evaluation of butylphthalide soft capsule in the treatment of cognitive dysfunction in Parkinsons disease

作　　者：张宇宇[1] 吴佳莹[2] 马葵芬[2] 周华[1] ZHANG Yu-yu;WU Jia-ying;MA Kui-fen;ZHOU Hua(Department of Pharmacy,Ningbo City Medical Treatment Center Lihuili Hospital,Ningbo,Zhejiang 315040,China)

机构地区：[1]宁波市医疗中心李惠利医院药学部,浙江宁波315040 [2]浙江大学医学院附属第一医院药学部,浙江杭州310003

出　　处：《中华全科医学》2020年第10期1753-1757,共5页Chinese Journal of General Practice

基　　金：国家自然科学基金(81402907);浙江省自然科学基金(LY19H310007);浙江省医药卫生科技计划项目(2019KY604);浙江省药学会医院药学专项科研资助项目(2018ZYY36);宁波市医学科技计划(2016A31)。

摘　　要：目的对丁苯酞软胶囊治疗帕金森病认知功能障碍的有效性进行系统评价。方法检索国内外数据库中丁苯酞软胶囊治疗帕金森病认知功能障碍的随机对照研究,利用Revman5.1进行Meta分析。结果共纳人9篇文献,755名受试者。从系统评价结果来看:与对照组相比,丁苯酞软胶囊能显著降低UPDRS评分[MD=-11.16,95%CI(-14.07^-8.25),P<0.001],能显著增加MoCA评分[MD=3.22,95%CI(2.39~4.05),P<0.001],能显著增加MMSE评分[MD=3.05,95%C1(2.24~3.87),P<0.001],能显著增加ADL评分[MD=13.05,95%C(11.53~14.57),P<0.001];能显著降低CRP水平[MD=-2.69,95%CI(-2.69^-2.27),P<0.001],能显著升高NT-3水平[MD=8.48,95%CI(7.35~9.61),P<0.001],能显著降低PARK7水平[MD=-10.88,95%CI(-12.35-9.40),P<0.001]。结论丁苯酞软胶囊能有效改善帕金森病认知功能障碍,效果显著。但本次研究存在--定的局限性,仍需设计更为良好的临床随机对照研究来验证。Objective To systematically evaluate the fficacy of butylphthalide soft capsule in the treatment of cognitive impairment in Parkinsons disease.Methods Randomized controlled trials of butylphthalide soft capsules in the treat-ment of cognitive impairment in Parkinsons disease were retrieved from domestic and foreign databases.Revman5.1 was used for meta-analysis.Results A total of 9 articles and 755 subjects were included.Compared with the control group,butylphthalide soft capsules could significanly reduce UPDRS score[MD=-11.16,95%CI(-14.07 to-8.25),P<0.001],and increase MoCA score[MD=3.22,95%CI(2.39-4.05),P<0.001],MMSE score[MD=3.05,95%CI(2.24-3.87),P<0.001],and ADL score[MD=13.05,95%CI(11.53-14.57),P<0.001].It could significantly reduce CRP level[MD=-2.69,95%CI(-2.69 to-2.27),P<0.001]and PARK7 level[MD=-10.88,95%CI(-12.35 to-9.40),P<0.001],and significantly increase NT-3 level[MD=8.48,95%CI(7.35-9.61),P<0.001].Conclusion Butylphthalide soft capsule can signifcantly improve the cognitive impair-ment of Parkinsons disease.However,there are some limitations in this study,which still need to be verified by a better clinical randomized controlled study.

关 键 词：丁苯酞 帕金森病 认知功能障碍 META分析 

分 类 号：R742.5[医药卫生—神经病学与精神病学]