IA-IIB期宫颈癌中患者临床病理特征及预后影响因素分析  

Analysis of clinicopathological features and prognostic factors of IA-IIB cervical cancer

作　　者：米热阿叶·阿布都热西提 赵雅文 张旭娟 杨艳[1] 薛茜文 陈志芳[1] Mireaye Abudurexiti;ZHAO Yawen;ZHANG Xujuan;YANG Yan;XUE Qianwen;CHEN Zhifang(Department of Gynecology, the First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院妇产科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2020年第8期993-996,1003,共5页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81660475);省部共建中亚高发病成因与防治国家重点实验室立项项目(SKL-HIDCA-2019-8)。

摘　　要：目的研究IA-IIB期宫颈癌临床病理特征及影响其预后的高危因素。方法回顾性分析2012-2017年于新疆医科大学第一附属医院妇科接受手术治疗的75例IA-IIB期宫颈癌患者的临床资料,并比较其临床病理特征,分析术后生存情况。结果75例宫颈癌患者中鳞癌患者61例(81.3%),腺癌患者14例(18.6%);高分化患者14例(18.7%),中分化患者33例(44%),低分化患者28例(37.3%);IA期患者11例(14.7%),IB期患者22例(29.3%),IIA期患者22例(29.3%),IIB期20例(26.7%)。单因素分析结果显示:病理类型、肿块大小、脉管侵犯和盆腔淋巴结转移与研究对象术后生存时间长短密切相关(P<0.05);多因素分析显示:病理类型、脉管侵犯和盆腔淋巴结转移为影响研究对象术后预后的独立危险因素。结论病理类型为腺癌、有脉管浸润及有淋巴结转移IA-IIB期宫颈癌患者预后较差。Objective To study the clinical and pathological characteristics of IA-IIB cervical cancer and the high-risk factors affecting its prognosis.MethodsThe clinical data of 75 patients with stage IA-IIB cervical cancer who underwent surgical treatment in the Gynecology Department of the First Affiliated Hospital of Xinjiang Medical University from 2012 to 2017 were retrospectively analyzed,and their clinical and pathological characteristics were compared.ResultsAmong them,61 were squamous cell carcinoma patients(81.3%),and 14 were adenocarcinoma patients(18.6%),in which there were 14 highly differentiated patients(18.7%),33 moderately differentiated patients(44%),28 poorly differentiated patients(37.3%);and there were 11 patients with stage IA(14.7%),22 patients with stage IB(29.3%),22 patients with stage IIA(29.3%)and 20 patients with stage IIB(26.7%).The univariate analysis showed that the pathological type,mass size,vascular invasion,and pelvic lymph node metastasis were closely related to the survival time of the subject after surgery(P<0.05).The multivariate analysis showed that pathological type,vascular invasion,and pelvic lymph node metastasis were independent risk factors that affected the prognosis of the postoperative subjects.ConclusionPatients with adenocarcinoma,vascular invasion and lymph node metastasis had poor prognosis.

关 键 词：宫颈癌 临床分期 病理诊断 预后 

分 类 号：R737.33[医药卫生—肿瘤]