正交试验联合人工神经网络优选活血散瘀泡腾片提取工艺  

The extraction process of Huoxue-Sanyu effervescent tablets by orthogonal test combined with artificial neural network

作　　者：彭伟 涂禾[1] 张忠[1] 祝贺[1] 周许 吴明权 Peng Wei;Tu He;Zhang Zhong;Zhu He;Zhou Xu;Wu Mingquan(TCM Research Laboratory,Sichuan Provincial Orthopedic Hospital,Chengdu 610041,China)

机构地区：[1]四川省骨科医院中药研究室,成都610041

出　　处：《国际中医中药杂志》2020年第6期573-578,共6页International Journal of Traditional Chinese Medicine

基　　金：四川省骨科医院科研项目(2015-23)。

摘　　要：目的优选活血散瘀泡腾片的提取工艺。方法以芍药苷与羟基红花黄色素A含量、干膏收率为评价指标,采用层次分析法、多指标综合评分法结合正交试验、Back Propagation(BP)人工神经网络优选加水量、提取时间、提取次数等工艺参数。结果芍药苷和羟基红花黄色素A分别在0.0795~1.5904μg、0.0385~1.5392μg范围内线性关系良好,平均回收率分别为98.18%、96.22%,RSD分别为0.77%、1.31%。确定活血散瘀泡腾片最佳提取工艺为9倍量水,加热回流提取3次,每次1 h。结论正交试验联合BP人工神经网络优化方法实用高效,优选的提取工艺科学合理,稳定可行。Objective To optimize the extraction process of Huoxue-Sanyu effervescent tablets.Methods The hydroxysafflor yellow A content,paeoniflorin and dry extract yield were used as the evaluation indexes,by using analytic hierarchy process(AHP)method,integrative graded indicators method combined with orthogonal test and back propagation(BP)artificial neural network.To optimize the technics parameters,such as the amount of water,extraction time and frequency.Results Paeoniflorin and hydroxysafflor yellow A showed good linear relation in the range of 0.0795-1.5904μg and 0.0385-1.5392μg respectively,with the average recovery rates of 98.18%and 96.22%.RSD was 0.77%and 1.31%respectively.The optimum extraction technic was 9 times of water,3 times of heating reflux extraction,and each extraction last for 1 hour.Conclusions The optimized combined method of orthogonal experiment and BP artificial neural network is practical with high efficiency.The optimal extraction process is stable and reasonable.

关 键 词：芍药苷 羟基红花黄色素A 正交试验 人工神经网络 活血散瘀泡腾片 

分 类 号：R283.6[医药卫生—中药学]