台湾海峡西岸地区环境危险因素与成人急性白血病易感性的病例对照研究  

A Case-control Study of Environmental Risk Factors Associated with Adult Acute Leukemia susceptibility in the West Coast of the Taiwan Strait

作　　者：李会宁 刘彦权 赖桂兰 沈建箴[1] LI Huining;LIU Yanquan;LAI Guilan;SHEN Jianzhen(Department of Hematology,Fujian Medical Universial Union Hospital,Fujian Institute of Hematology,National and Fujian Provincial Key Laboratory of Hematology,Fuzhou 350001,China)

机构地区：[1]福建医科大学附属协和医院血液内科,福建省血液病研究所,国家及福建省血液病学重点实验室,福建福州350001

出　　处：《中国医药指南》2020年第23期4-6,共3页Guide of China Medicine

基　　金：福建省科技创新联合资金项目(2018Y9010);中青年骨干人才培养项目(2018-ZQN-40);福建省卫计委中青年骨干人才培养项目(2016-ZQN-29);福建省自然科学基金青年项目(2017J05132);福建医科大学启航基金项目(2016QH020);福建省血液医学中心建设项目资助(闽政办[2017]171号);国家和福建省临床重点专科建设项目资助(闽卫医函[2011]1018号、闽卫科教[2012]149号)。

摘　　要：目的探讨台湾海峡西岸地区环境危险因素与成人急性白血病(AL)易感性的关系。方法采用回顾性调查研究方法,选取福建医科大学附属协和医院2015年10月至2018年5月收治的成人AL患者69例作为试验组,另选同期健康体检者74名作为对照组。以问卷形式调查受试者的一般情况以及吸烟、X线照射、装修史等环境危险因素。对两组一般情况、环境危险因素进行χ^2检验,选取有统计学意义的危险因素进行多因素Logistic回归分析。结果多因素Logistic回归分析显示,居所装修史(OR=3.479,95%CI:1.575~7.685)、家中不通风(OR=3.430,95%CI:1.518~7.754)、吸烟史(OR=2.679,95%CI:1.175~6.111)、靠近公路(OR=2.231,95%CI:1.034~4.813)有统计学意义。结论在台湾海峡西岸地区,居所装修史、家中不通风、吸烟史及居所靠近公路可能是成人急性白血病的易感因素。Objective To explore the relationship of environmental risk factors and adult acute leukemia(AL)susceptibility in the west coast of the Taiwan Strait.Methods Using retrospective research methods,69 adult AL patients admitted to Fujian Medical University Affiliated Union Hospital from October 2015 to May 2018 were selected as the experimental group,and 74 cases of health examination during the same period were selected as the control group.Use questionnaires to investigate the general conditions and environmental risk factors such as smoking,X-ray exposure,and decoration history of the subjects.χ^2 test was performed on the general conditions and environmental risk factors of the two groups,and multivariate logistic regression analysis was performed on the statistically significant indicators of single factor analysis.Results Multivariate logistic regression analysis showed that the history of home decoration(OR=3.479,95%CI:1.575-7.685),lack of ventilation in the home(OR=3.430,95%CI:1.518-7.754),smoking history(OR=2.679,95%CI:1.175-6.111),living by the road(OR=2.231,95%CI:1.034-4.813)were statistically significant.Conclusion On the west coast of the Taiwan Strait,home decoration history,lack of ventilation in the home,smoking history,and proximity to roads,may be susceptible factors for adult AL.

关 键 词：急性白血病 环境因素 易感性 多因素LOGISTIC回归分析 

分 类 号：R733.71[医药卫生—肿瘤] R181.3[医药卫生—临床医学]