早期乳腺癌保乳术后不同剂量调强放射治疗疗效比较  

Comparison of therapeutic effects of intensity-modulated radiotherapy with different dose schemes following breast-conserving surgery for early-stage breast cancer

作　　者：陈日新[1] 罗展雄[1] 秦佳宁[1] 朱州[1] 贾燕华 王志 CHEN Rixin;LUO Zhanxiong;QIN Jia'ning;ZHU Zhou;JIAYanhua;WANG Zhi(Department of Medical Oncology,Liuzhou People's Hospital,Liuzhou 545006,China;Department of General Practice,Affiliated Hospital of Xiangnan University,Chenzhou 423000,China)

机构地区：[1]柳州市人民医院肿瘤内科,广西柳州545006 [2]湘南学院附属医院全科医疗科,湖南郴州423000

出　　处：《中国医学物理学杂志》2020年第8期993-995,共3页Chinese Journal of Medical Physics

基　　金：广西壮族自治区卫健委课题(Z20180289)。

摘　　要：目的:分析早期乳腺癌保乳术后不同剂量调强放射治疗效果。方法:接受手术治疗的乳腺癌患者50例,依据不同放射剂量分组:A组放疗总剂量50 Gy,B组放疗总剂量60 Gy,观察两种方案的干预效果及安全性。结果:两组患者在V100%上并无差异,分别为(55.13±6.28)%和(54.26±6.01)%;在V99%、V109%、V115%等比较均存在显著差异(P<0.05)。A组3年复发率12%,高于B组的4%(P<0.05);A组患者Ⅰ级及以下放射性皮炎发生率44.00%,显著低于B组的72.00%(P<0.05),两组Ⅱ级与Ⅲ级及以上放射性皮炎发生率无显著差异。结论:早期乳腺癌患者以保乳术作为主要治疗方案,放射疗法属于关键辅助措施,不同剂量影响治疗效果,适当增大剂量有助于提升整体疗效。Objective To analyze the therapeutic effects of intensity-modulated radiotherapy with different dose schemes after breastconserving therapy for early-stage breast cancer.Methods Fifty patients receiving surgery for breast cancer were divided into two groups according to the irradiation dose.The total radiotherapy dose was 50 Gy in groupAand 60 Gy in group B.The intervention effect and safety of the two schemes were analyzed.Results There were significant differences between two groups in V99%,V109%and V115%(P<0.05),but not in V100%[(55.13±6.28)%vs(54.26±6.01)%].The 3-year relapse rate in groupAwas 12%,higher than 4%in group B(P<0.05).Moreover,the incidence of radiodermatitis of gradeⅠand below in group A was obviously lower than that in group B(44.00%vs 72.00%,P<0.05),and no significant difference was found in the incidence of radiodermatitis of gradeⅡand grade III and above.Conclusion The main treatment scheme for patients with early-stage breast cancer is breast-conserving therapy,and the key auxiliary measure is radiotherapy in which different dose schemes can affect the therapeutic effect,and an appropriate high dose scheme can improve the overall therapeutic effect.

关 键 词：乳腺癌 保乳术 调强放射治疗 放射剂量 

分 类 号：R730.55[医药卫生—肿瘤] R811.1[医药卫生—临床医学]