胃癌患者癌组织中赖氨酸去甲基化酶3A的表达及临床意义  

Expression of KDM3A in Cancer Tissues of Patients with Gastric Cancer and Its Clinical Significance

作　　者：杜天明 严群[2] 王向阳[1] 何承志 王辉[1] Du Tianming;Yan Qun;Wang Xiangyang(Department of Gastrointestial Surgery,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430014,China;Department of Gastrointestial Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属武汉中心医院胃肠外科,武汉430014 [2]华中科技大学同济医学院附属同济医院胃肠外科,武汉430030

出　　处：《华中科技大学学报（医学版）》2020年第4期481-485,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省自然科学基金资助项目(No.2019CFC845)。

摘　　要：目的探讨赖氨酸去甲基化酶3A(KDM3A)在胃癌组织中的表达及临床意义。方法回顾性分析武汉市中心医院胃肠外科2012年1月到2014年12月收治的胃癌患者术后组织标本100例,采用免疫组化方法检测胃癌组织中KDM3A表达,并根据免疫组化结果分为KDM3A高、低表达两组,采用Kaplan-Meier曲线法和Log-rank检验比较KDM3A高、低表达组患者无瘤生存率和总生存率的差异,采用Cox比例风险模型分析影响胃癌患者无瘤生存率和总生存率的独立危险因素。结果KDM3A高表达者比例为58.0%(58/100),KDM3A低表达者比例为42.0%(42/100)。KDM3A的表达与胃癌患者TNM分期(P=0.006)和N分类(P=0.010)显著相关。KDM3A高表达组患者5年无瘤生存率显著低于KDM3A低表达组患者(18.7%vs.28.5%,P=0.009)。KDM3A高表达组患者5年总生存率显著低于KDM3A低表达组患者(21.4%vs.33.2%,P=0.003)。单因素分析结果显示:TNM分期、T分类、N分类和KDM3A表达是影响患者无瘤生存率的危险因素(均P<0.05);多因素分析显示TNM分期(P=0.010)及KDM3A表达(P=0.037)是影响患者无瘤生存率的独立危险因素。单因素分析结果显示:TNM分期、N分类、组织学分化和KDM3A表达是影响患者总生存率的危险因素;多因素分析显示组织学分化(P=0.038)及KDM3A表达(P=0.002)是影响患者总生存率的独立危险因素。结论KDM3A是影响胃癌患者预后的新的分子标志物。Objective To investigate the expression and clinical significance of lysine demethylase 3A(KDM3A)in gastric cancer tissue.Methods The cancer tissues of 100 patients with gastric cancer admitted to our hospital from January 2012 to December 2014 were collected.The expression of KDM3A in gastric cancer tissues was detected by immunohistochemistry,and the patients were divided into KDM3A high and low expression groups,according to the results of the immunohistochemistry results.Kaplan-Meier curve and log-rank test were used to compare the difference of tumor-free survival rate and overall survival rate between KDM3A high and low expression groups.Cox proportional hazards model was used to analyze the risk factors influencing the tumor-free survival rate and overall survival rate of gastric cancer.Results The proportion of patients with high expression of KDM3A was 58.0%(58/100),and the proportion of patients with low expression of KDM3A was 42.0%(42/100).The expression of KDM3A was significantly associated with TNM stage(P=0.006)and N classification(P=0.010).The 5-year tumor-free survival rate of gastric cancer patients with high expression of KDM3A was significantly lower than that of patients with low expression of KDM3A(18.7%vs.28.5%,P=0.009).The 5-year overall survival rate of KDM3A high expression group was significantly lower than that of KDM3A low expression group(21.4%vs.33.2%,P=0.003).Univariate analysis showed that TNM stage,T classification,N classification and KDM3A expression were risk factors affecting the tumor-free survival rate(P<0.05).Multivariate analysis showed that TNM stage(P=0.010)and KDM3A expression(P=0.037)were independent risk factors for the tumor-free survival rate.Univariate analysis showed that TNM stage,N classification,histological differentiation and KDM3A expression were independent risk factors affecting the overall survival rate of patients.Multivariate analysis showed that histological differentiation(P=0.038)and KDM3A expression(P=0.002)were independent risk factors affecting t

关 键 词：KDM3A 胃癌 表达 临床意义 

分 类 号：R735.2[医药卫生—肿瘤]