Semiconducting quantum dots:Modification and applications in biomedical science  

半导体量子点:修饰及其在生物医学中的应用

作　　者：Lude Wang Duo Xu Jie Gao Xiang Chen Yanhong Duo Han Zhang 王路得;许多;高洁;陈翔;朵燕红;张晗(International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education,Institute of Microscale Optoelectronics,Shenzhen University,Shenzhen 518060,China;Institute of Optoelectronics&Nanomaterials,MIIT Key Laboratory of Advanced Display Materials and Devices,School of Materials Science and Engineering,Nanjing University of Science and Technology,Nanjing 210094,China;Department of Microbiology,Tumor and Cell Biology,Karolinska Institute,Stockholm 17177,Sweden)

机构地区：[1]International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education,Institute of Microscale Optoelectronics,Shenzhen University,Shenzhen 518060,China [2]Institute of Optoelectronics&Nanomaterials,MIIT Key Laboratory of Advanced Display Materials and Devices,School of Materials Science and Engineering,Nanjing University of Science and Technology,Nanjing 210094,China [3]Department of Microbiology,Tumor and Cell Biology,Karolinska Institute,Stockholm 17177,Sweden

出　　处：《Science China Materials》2020年第9期1631-1650,共20页中国科学（材料科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(61875138,61435010 and 6181101252);the Science and Technology Innovation Commission of Shenzhen(KQTD2015032416270385,JCYJ20150625103619275 and JCYJ20170811093453105);China Postdoctoral Science Foundation(2019M663062);the support from the Instrumental Analysis Center of Shenzhen University(Xili Campus)。

摘　　要：Semiconductor quantum dots(SQDs)have received much attention due to their high quantum yield(QY),tunable emission spectrum,and excellent photostability.These unique optical properties endow SQDs with excellent biomedical application prospects,including biomedical imaging,drug delivery,clinical diagnosis,photodynamic therapy,DNA hybridization,and RNA profiling.This review introduces the classification of QDs and provides a brief description of the characteristics of QDs under each classification.Taking the type II B-VI A QDs as an example,inorganic and organic modification methods,and the corresponding advantages and disadvantages are summarized and discussed.Controlled modification approaches make them exhibit different functions in the bioimaging and drug delivery fields.The typical or classic instances are also listed to present the highlights of the applications of SQDs in the biomedical field.Based on these,this review raises a variety of possible challenges and perspectives of SQDs in biomedical applications in the future.半导体量子点由于其高量子产率、可调谐的发射光谱和优异的光稳定性而受到人们的广泛关注.这些独特的光学特性赋予半导体量子点在生物医学领域中出色的应用前景,譬如量子点可在生物医学成像、药物输送、临床诊断、光动力疗法、DNA杂交和RNA分析等领域中得以应用.本综述介绍了量子点的分类,并简要描述了每类量子点的特征.以II B-VI A型量子点为例,分别讨论和总结了其无机和有机修饰方法及相应的优缺点.基于可控的修饰方法,量子点在生物成像和药物传递领域表现出不同的功能.本文还列出了量子点的一些典型或经典实例,用于介绍半导体量子点在生物医学领域中的应用亮点.以此为基础,本综述提出了半导体量子点在未来生物医学领域中的各种潜在挑战和应用前景.

关 键 词：semiconducting quantum dots MODIFICATION imaging drug delivery BIOMATERIALS 

分 类 号：R318[医药卫生—生物医学工程] O471.1[医药卫生—基础医学]