POM121在结肠癌组织中的表达及临床意义  

The expression and clinical significance of nuclear pore membrane protein 121 in colon cancer

作　　者：李利[1] 贾立周 赵薇[3] 唐奇[2] LI Li;JIA Lizhou;ZHAO Wei;TANG Qi(HuiQiao Medical Centre,Nanfang Hospital,Nanfang Medical University,Guangzhou 510515;Department ofPathology,Nanjing Medical University,Nanjing 211166;Department of Pathology,the Affiliated Nanjing Hospitalof Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南方医科大学南方医院惠侨医疗中心,广东广州510515 [2]南京医科大学病理学系,江苏南京211166 [3]南京医科大学附属南京医院病理科,江苏南京210006

出　　处：《南京医科大学学报（自然科学版）》2020年第7期963-968,990,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81773100)。

摘　　要：目的:探讨核孔膜蛋白121(nuclear pore membrane protein 121,POM121)表达与结肠癌病理特征的相关性及其对临床预后的意义。方法:应用免疫组织化学SP法检测POM121在结肠癌组织和癌旁组织中的表达水平;结合临床资料,分析POM121表达情况与结肠癌临床病理特征和患者预后的联系;使用基因富集分析初步探究POM121在结肠癌发生发展中的可能作用机制。结果:POM121在结肠癌组织中高表达的比例(66.03%)高于癌旁组织(47.42%),差异具有统计学意义(P<0.001);结肠癌组织中POM121表达与肿瘤大小(P=0.041)、淋巴结转移(P<0.001)、远处转移(P=0.002)、AJCC分期(P=0.003)、静脉浸润(P<0.001)、嗜神经侵袭(P<0.001)、术前癌胚抗原(P<0.001)、术前糖类抗原199(P=0.004)、Ki67(P<0.001)有相关性,与性别、年龄、部位、组织学类型、分化无关;POM121高表达的结肠癌患者总体生存率较低;高POM121表达的结肠癌组织中基因富集于氨基酰基t-RNA生物合成、碱基切除修复、DNA复制等途径。结论:POM121在结肠癌中高表达,是影响患者预后的独立危险因素,有望成为新的结肠癌预后标志物和靶向治疗的分子靶点。Objective:To explore the relationship between nuclear pore membrane protein 121(POM121)expression and pathological characteristics of patients with colon cancer and the significance of POM121 to patients’prognosis.Methods:Immunohistochemistry was used to detected POM121 level in colon cancer tissues and para-carcinoma tissues.Based on the clinical data of patients,the connection between POM121 expression and clinical pathological characteristics of colon cancer was analyzed,as well as the significance of POM121 to clinical prognosis.Results:The positive expression rate of POM121 in colon cancer tissues(66.03%)was higher than that in para-carcinoma tissues(47.42%)with a statistically significant difference(P<0.001).The expression of POM121 was significantly correlated with tumor siae(P=0.041),lymph node metastasis(P<0.001),distant metastasis(P=0.002),the AJCC staging(P=0.003),venous invasion(P<0.001),perineural invasion(P<0.001),preoperative carcino-embryonic antigen(P<0.001),preoperative carbohydrate antigen 199(P=0.004),and Ki67(P<0.001)expression,while no correlation was found between the POM121 expression and gender,age,location,histological type,or differentiation.Patients with high POM121 expression had poor overall survival rates.Genes in colon cancer tissues with high POM121 expression were enriched in aminoacyl t-RNA biosynthesis,base excision repair,DNA replication and so on.Conclusion:POM121 is highly expressed in colon cancer and is an independent risk factor affecting the prognosis of patients.POM121 has the potential to become a new prognostic markers and molecular targets for targeted therapy of colon cancer.

关 键 词：结肠癌 POM121 预后 

分 类 号：R735.3[医药卫生—肿瘤]