中医外治法治疗脑卒中急性期患者胃肠功能紊乱Meta分析  

Meta Analysis of External Treatment of Chinese Medicine for Patients with Gastrointestinal Dysfunction at Acute Stage of Stroke

作　　者：陈发军[1] 周凯欣[1] 朱晶[1] CHEN Fajun;ZHOU Kaixin;ZHU Jing

机构地区：[1]广东省中医院,广东广州510120

出　　处：《新中医》2020年第14期14-19,共6页New Chinese Medicine

基　　金：广东省中医药局课题(20181109)。

摘　　要：目的:应用Meta分析方法系统评价中医外治法治疗脑卒中后患者胃肠功能紊乱的有效性和安全性。方法:运用RevMan 5.3软件对建库至2019年1月31日国内外发表的关于中医外治法治疗脑卒中急性期患者胃肠功能紊乱的随机对照试验(RCT)进行Meta分析。结果:中医外治法可提高脑卒中急性期患者的临床有效率(OR=4.48,95%CI[2.27,8.84]),减少便秘发生率(OR=0.28,95%CI[0.22,0.35]),缩短首次排便时间(SMD=-1.00,95%CI[-1.29,-0.72])。结论:中医外治法不仅可以降低脑卒中急性期患者的便秘发生率,提高临床有效率,并可加快首次排便时间,但其远期疗效及安全性仍需更多高质量及大样本的RCT加以验证。Objective: To systematically evaluate the effect and safety of external treatment of Chinese medicine for patients with gastrointestinal dysfunction with stroke by using Meta analysis method. Methods:The randomized controlled trials(RCT) on the external treatment of Chinese medicine published at home and abroad from the establishment day of the database to January 31,2019 for patients with gastrointestinal dysfunction at acute stage of stroke were under Meta analysis by via RevMan 5.3 software. Results:The external treatment of Chinese medicine can improve the clinical effect in patients at acute stage of stroke(OR= 4.48,95%CI [2.27,8.84]),reduce the incidence of constipation(OR=0.28,95%CI [0.22,0.35]),shorten the time of first defecation(SMD=-1.00,95%CI [-1.29,-0.72]). Conclusion:The external treatment of Chinese medicine can reduce the incidence of constipation in patients with acute stroke,improve the clinical effect,and accelerate the time of the first defecation,but its long-term effect and safety still need to be verified by more high-quality and largesample RCT.

关 键 词：脑卒中 胃肠道功能紊乱 中医外治法 随机对照试验 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R574.4[医药卫生—临床医学]