β-七叶皂苷钠联合脑安胶囊对脑梗死恢复期气虚血瘀证病人预后的影响  

Effect ofβ-Aescinate Sodium and Naoan Capsule on the Prognosis of Patients with Qi Deficiency and Blood Stasis Syndrome in Convalescent Stage of Cerebral Infarction

作　　者：王建阔 唐晓颖 李恒周[1] 范东梅 刘永胜[1] 刘立杰[1] 刘晨庆 WANG Jiankuo;TANG Xiaoying;LI Hengzhou;FAN Dongmei;LIU Yongsheng;LIU Lijie;LIU Chenqing(Second Hospital of Baoding,Baoding 071051,Hebei,China;Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China)

机构地区：[1]保定市第二医院,河北保定071051 [2]河北大学附属医院,河北保定071000

出　　处：《中西医结合心脑血管病杂志》2020年第15期2502-2506,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨β-七叶皂苷钠联合益气通络法(脑安胶囊)对脑梗死恢复期气虚血瘀证病人预后的影响。方法选取保定市第二医院收治的脑梗死恢复期气虚血瘀证病人100例,按随机化设计分为对照组与观察组,每组50例。对照组采用脑梗死恢复期常规治疗,观察组在此基础上加用β-七叶皂苷钠联合益气通络脑安胶囊治疗,比较两组治疗效果及中医证候积分变化,评定两组治疗不同时间美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(BI指数)评分变化,检测治疗前后病人血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、纤维蛋白原(Fib)、全血高切黏度、全血低切黏度、血浆黏度等指标的变化,并采用改良Rankin量表(mRS)评分评定病人预后,统计随访不良事件发生率。结果治疗3个月后,两组言语蹇涩、偏瘫、半身不遂、口舌歪斜、气短乏力积分均降低(P<0.05或P<0.01),观察组治疗后各积分均较对照组降低(P<0.05);观察组治疗总有效率高于对照组(P<0.05或P<0.01);治疗3个月后,两组NIHSS评分降低,BI指数评分上升,hs-CRP、Hcy、Fib、全血高切黏度、全血低切黏度、血浆黏度降低(P<0.05),观察组治疗后NIHSS评分及hs-CRP、Hcy、Fib、全血高切黏度、全血低切黏度、血浆黏度水平均低于对照组,BI指数评分高于对照组(P<0.05或P<0.01);观察组mRS评分为1分所占比例高于对照组(P<0.05),评分为3分、4分所占比例明显低于对照组(P<0.05),两组随访不良事件发生率比较差异无统计学意义(P>0.05)。结论β-七叶皂苷钠联合益气通络脑安胶囊治疗脑梗死恢复期气虚血瘀证,可显著改善病人症状及体征,减轻神经功能缺损程度,提升日常生活能力,降低血液黏度,改善预后。Objective To investigate the effect ofβ-aescin sodium and Naoan capsule(NAC)on the prognosis of patients with qi deficiency and blood stasis syndrome in convalescence of cerebral infarction.Methods One hundred patients with qi deficiency and blood stasis syndrome in convalescent stage of cerebral infarction were selected and randomly divided into two groups:control group(n=50)and observation group(n=50).The patients were treated with routine treatment in control group,andβ-aescin sodium plus NAC in observation group for 3 months.The effects of treatment and the changes of traditional Chinese medicine(TCM)symptom integral were compared between the two groups.The National Institutes of Health Stroke Scale(NIHSS)score and daily living ability of the two groups at different time were evaluated,and the patients before and after treatment were detected.The changes of serum high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),fibrinogen(Fib),whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and other indicators before and after treatment were detected.The prognosis of patients was evaluated by modified Rankin(mRS).The incidence of adverse events in follow-up was calculated.Results After 3 months of treatment,the scores of speech Jian,hemiplegia,slanting tongue and asthenia were decreased in both groups(P<0.05),which were lower in the observation group than those in the control group(P<0.05).The total effective rate in the observation group was higher than that in the control group(P<0.05).After 3 months of treatment,NIHSS score decreased,BI index score increased,hs-CRP,Hcy,Fib,whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity decreased in both groups(P<0.05).NIHSS score,hs-CRP,Hcy,and Fib levels in observation group after treatment were lower than those in control group(P<0.05).The whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity level in observation group were lower than those of the control group.The BI

关 键 词：脑梗死 Β-七叶皂苷钠 恢复期 脑安胶囊 气虚血瘀证 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]