丁苯酞注射液联合丹红注射液治疗急性脑梗死的临床疗效及对氧化应激指标、血管内皮生长因子水平的影响  

Clinical Effect of Butylphthalide Injection Combined with Danhong Injection on Acute Cerebral Infarction and its Influence with Oxidative Stress Index and Vascular Endothelial Growth Factor

作　　者：薛伟新 黄庆嘉 陈炜[3] XUE Weixin;HUANG Qingjia;CHEN Wei(Hezhou Hospital of Traditional Chinese Medicine,Hezhou 542899,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)

机构地区：[1]贺州市中医医院,广西贺州542899 [2]广西中医药大学 [3]广西中医药大学第一附属医院,南宁530023

出　　处：《中西医结合心脑血管病杂志》2020年第15期2513-2516,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金(No.81760847);广西科技计划项目重点研发计划(No.桂科AB16380324);广西中医基础研究重点实验室系统课题(No.17-259-49-01);广西中医药大学青年创新研究团队(No.2016QT004);广西中医药大学岐黄工程高层次人才团队培育项目资助(No.2018003)。

摘　　要：目的探讨丁苯酞注射液联合丹红注射液治疗急性脑梗死的临床疗效及对氧化应激指标、血管内皮生长因子水平的影响。方法将符合纳入标准的86例急性脑梗死病人按随机数字表法随机分为对照组与治疗组,各43例。两组病人均常规给予脑梗死方案常规治疗,对照组在基础治疗上加用丹红注射液30 mL加入0.9%氯化钠注射液250 mL,静脉输注,1次/天;治疗组在对照组的基础上加用丁苯酞氯化钠注射液100 mL,静脉滴注,2次/天。两组疗程均为14 d。观察两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力Barthel指数(BI)评分以及血清血管内皮生长因子(VEGF)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果治疗组总有效率为93.02%,对照组总有效率为79.06%,治疗组优于对照组(P<0.05)。经治疗后,两组NIHSS评分均较治疗前下降,差异有统计学意义(P<0.05),且治疗组优于对照组(P<0.05);两组BI评分均较治疗前上升,差异有统计学意义(P<0.05),且治疗组优于对照组(P<0.05);两组血清VEGF、SOD水平均较治疗前上升,差异有统计学意义(P<0.05),且治疗组优于对照组(P<0.05)。两组血清MDA水平均较治疗前下降,差异有统计学意义(P<0.05),且治疗组优于对照组(P<0.05)。结论丁苯酞注射液联合丹红注射液治疗急性脑梗死临床疗效显著,能够改善急性脑梗死病人的神经损伤程度,提高日常生活能力,促进血管新生,减轻自由基反应。Objective To investigate the clinical efficacy of butylphthalide injection combined with Danhong injection in the treatment of acute cerebral infarction and its influence on oxidative stress index and vascular endothelial growth factor.Methods Eighty-six patients with acute cerebral infarction were randomly divided into control group and treatment group,43 cases in each group.Two groups were given routine treatment of acute cerebral infarction.The control group was treated with Danhong injection on the basis of basic treatment for 14 days,and the treatment group was given butylphthalide injection on the basis of control group for 14 days.National Institutes of Health Stroke Scale(NIHSS)score,Barthel Index(BI)score,vascular endothelial growth factor(VEGF),superoxide dismutase(SOD),and malondialdehyde(MDA)were compared between two groups.Results The clinical efficacy in the treatment group was better than that in the control group(93.02%vs 79.06%,P<0.05).After treatment,the NIHSS scores of the two groups were lower than those before treatment,(P<0.05),and that in the treatment group was better than that in the control group(P<0.05).The BI scores of the two groups were higher than those before treatment(P<0.05),and that in the treatment group was better than that in the control group(P<0.05).The levels of VEGF and SOD in the two groups were higher than those before treatment(P<0.05),and those in the treatment group was better than those in the control group(P<0.05).The level of MDA in the two groups were lower than that before treatment(P<0.05),and that in the treatment group was better than that in the control group(P<0.05).Conclusion Butylphthalide injection combined with Danhong injection had significant clinical efficacy in the treatment of acute cerebral infarction,which could improve the degree of nerve injury,improve the ability of daily life,promote angiogenesis,and reduce free radical reaction.

关 键 词：急性脑梗死 丁苯酞注射液 丹红注射液 氧化应激指标 血管内皮生长因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]